The Changes in the Body-perception and Perception of the Pain in Patients With Anorexia Nervosa Before and After Using the tDCS
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Anorexia Nervosa
- Sponsor
- Silvie Ceresnakova
- Enrollment
- 43
- Locations
- 1
- Primary Endpoint
- Change of the Eating Disorders Examination Questionnaire (EDEq) score
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Anorexia Nervosa (AN) is a serious and often chronical eating disorder characterized by an extreme effort for weight loss and intense fear of becoming fat despite the obvious thinness. The treatment is very difficult and not always effective. That´s the reason why we are looking for new ways of the therapeutic approach.
Transcranial direct current stimulation (tDCS) is a neuromodulation technique, which modulates the neuronal excitability. According to previous research it has a potential to help people with Anorexia Nervosa.
The device for the tDCS has two electrodes, an anode (the excitatory one) and a cathode (the inhibitory one). We put them on the skull into the different positions, in dependence on the fact, if we want to excite or on to inhibit the parts of the brain under the electrodes.
There are several hypothesis how could the tDCS help in patients with AN. One of them speaks about the hyperactivity of the right hemisphere in Anorexia Nervosa. Therefore could the anodal (excitatory) tDCS over the left hemisphere and the cathodal (inhibitory one) help in resetting the inter-hemispheric balance.
Detailed Description
Stimulation of 2 milliampere is applied for 30 minutes in every real session. Together there are 10 sessions, the application is every workday within 2 weeks. All measurements and questionnaires are made 4 times: 1. Before the stimulation 2. On the day of the last stimulation 3. 14 days after the last stimulation 4. 28 days after the last stimulation
Investigators
Silvie Ceresnakova
Principal Investigator
Charles University, Czech Republic
Eligibility Criteria
Inclusion Criteria
- •patients with the diagnosis of anorexia nervosa
Exclusion Criteria
- •patients: with the diagnosis of epilepsy, after a serious injury of head, with chronic headache, with some metal or electronic implants in their heads and patients who are pregnant.
Outcomes
Primary Outcomes
Change of the Eating Disorders Examination Questionnaire (EDEq) score
Time Frame: 8 weeks
Comparison of the total scores and subscores of the Eating Disorders Examination Questionnaire (EDEq)
Secondary Outcomes
- Change of the Zung Self-Rating Depression Scale(8 weeks)
- Change of the weight in kilograms(8 weeks)
- Change of the pain threshold(8 weeks)