Tradeoff Between Spatial and Temporal Resolution

Terminated

• Conditions: Deafness
• Interventions: Behavioral: Electrode selection/electrode configuration

• Registration Number: NCT03867058
• Lead Sponsor: East Carolina University

Brief Summary

In this study, investigators will examine how temporal rate processing might be affected when the width of neural excitation narrows. The manipulation of neural excitation width will be achieved for example by changing electrode configurations or stimulating single versus multiple electrodes simultaneously. Investigators will then measure if the extent to which rate processing is affected by spatially restricted stimulation can predict a subject's overall speech recognition and predict also whether the subject is likely to benefit from a focused electrode configuration. Lastly, investigators will introduce and test a novel current focusing strategy where current focusing is applied in a channel specific manner and quantify if this intervention improves speech recognition. The primary endpoint of the study is speech recognition, and the secondary endpoint is psychophysical sensitivity to stimulation rate change.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-03-05
• Study First Submitted QC: 2019-03-06
• Study First Posted: 2019-03-07
• Study Start: 2019-10-01
• Status Verified: 2023-04
• Primary Completion: 2023-04-04
• Study Completion: 2023-04-04
• Last Update Submitted: 2023-04-06
• Last Update Posted: 2023-04-07

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 53

Inclusion Criteria

• Native speakers of English
• Cochlear Nucleus cochlear implant users or Advanced Bionics users
• Postlingually deafened
• Has had device experience for at least one year
• Can be child or adult at the time of enrollment

Exclusion Criteria

• None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cochlear implant users with Nucleus and AB devices	Electrode selection/electrode configuration	Temporal processing acuity will be compared using electrodes or electrode configurations that create broad versus sharp spatial excitation. Speech recognition will be compared in the same group of subjects using electrode-dependent focused versus monopolar stimulation.

Primary Outcome Measures

Name	Time	Method
Sensitivity to stimulation rate change at threshold	starting 6 months post award notice and will take up to 4 years to complete	Subjects' psychophysical detection thresholds will be measured as a function of the rate of stimulation delivered to selected electrodes and selected electrode configuration
Discrimination of stimulation rate	starting 6 months post award notice and will take up to 4 years to complete	subjects' ability to discriminate stimulation rates will be measured as a function of base stimulation rates at selected electrodes and selected electrode configuration.

Secondary Outcome Measures

Name	Time	Method
Speech recognition	starting 6 months post award notice and will take up to 4 years to complete	Speech recognition in quiet and in noise will be measured under three conditions: 1. the traditional monopolar electrode configuration; 2. using current focusing on electrodes that show good sensitivity to rate change; 3. using current focusing on all electrodes.

Trial Locations

Locations (1)

Department of Communication Sciences and Disorders, ECU; 🇺🇸 Greenville, North Carolina, United States