Effect of food matrix on bioavailability of cocoa polyphenols

Conditions: De uitkomsten van deze studie gaan gebruikt worden voor een geplande vervolgstudie naar het effect van cacaopolyfenolen op de bloeddruk. Deze biobeschikbaarheidsstudie heeft zelf niet op een aandoening betrekking.
high blood pressure
Hypertension

Registration Number: NL-OMON31523

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 12

Inclusion Criteria

Male
Age 18-70 years
Body Mass Index (BMI) 19-30 kg/m2
Reported alcohol consumption < 28 alcohol units/week
Willing to refrain from food and foodsupplements that contain polyphenols during the study
Informed consent signed
Prepared to consume test products for the duration of the study and comply with the background diet.
Prepared to donate blood samples during the study, and prepared to fill out questionnaires.
Urine parameters within normal reference range as judged by the research physician
Clinical chemical parameters within the normal reference range as judged by research physician
Accessible veins on both arms as determined by research physician

Exclusion Criteria

Females
Being an employee of the AMC
A recorded history or current metabolic diseases, chronic gastrointestinal disorders, cardiovascular or renal disease
Currently on a medically prescribed diet, or slimming diet
Reported intense sporting activities > 10 hours/week
Subjects who receive medical treatment
Any surgery in the past 6 months
Use of systemic antibiotics in the past 3 months
Recent blood donation i.e. 1 month prior to the study and no planned blood donation during the study period
Known intolerance or allergy to cocoa, soy or lactose
Reported weight change ± 10% the past 6 months
Participation in another biomedical study 3 months before the start or during the study
The habit of smoking during the past year
Consuming meat and/or fish less than twice a week
Participation in night shift work