Impact of Anesthesia on cerebral oxygenatio
Not Applicable
Completed
- Conditions
- Health Condition 1: S00-T88- Injury, poisoning and certain other consequences of external causes
- Registration Number
- CTRI/2020/12/029813
- Lead Sponsor
- Indian Council of Medical Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 115
Inclusion Criteria
Patient of either gender aged 18 years and above undergoing emergency cranial surgery for acute TBI with moderate or severe GCS (12-3)
Exclusion Criteria
(i) No consent
(ii) Pregnant patients
(iii) Contraindication to study drugs (haemodynamically unstable patient, ASA 3 or 4)
(iv) Patients with maxillofacial injuries
(v) Patients with factors that will affect NIRS values (like underlying scalp haematoma or pneumocephalus)
(vi) Airway contamination or likelihood of pulmonary aspiration
(vii) Patients already intubated in casualty
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effect of induction with Etomidate, Thiopentone and Propofol on rScO2Timepoint: Baseline at 0 hours <br/ ><br>Postoperative at end of 24 hours
- Secondary Outcome Measures
Name Time Method (i) To evaluate the effect of anesthetic induced changes in systemic hemodynamic parameters,SpO2 and to correlate it with the changes in the bilateral rScO2 (ii) To correlate the volume of hemorrhage with rScO2 changes <br/ ><br>(iii) To see effect of anesthetic induction with etomidate on serum cortisol levels <br/ ><br>(iv) To see the prognosis of the patient at end of 30 days after surgery. <br/ ><br>Timepoint: 0 TO 30 DAYS