NCT07171047招募中不适用
Effects of Sodium Bicarbonate Supplementation on Endurance Performance and Physiological Responses During Simulated Cycling Competition
University of Salzburg2 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2025年9月15日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Endurance performance
研究概览
简要总结
This study is investigating whether taking sodium bicarbonate, a common supplement used by endurance athletes, can improve cycling performance during prolonged exercise and in a time trial. Sodium bicarbonate may help reduce muscle acidity, which could delay fatigue and improve performance. The goal of this study is to determine if this supplement can help athletes perform better during long, intense efforts like those seen in real competitions.
Participants in this study are well-trained cyclists who will complete two exercise trials in a laboratory setting. Each trial involves three hours of moderate cycling followed by a 20-30-minute time trial at maximum effort. Before each trial, participants will take either sodium bicarbonate or a placebo.
The study will measure performance outcomes, such as time trial results, as well as physiological responses, including heart rate, oxygen use, and muscle fatigue. Researchers hope to better understand how sodium bicarbonate can help endurance athletes and provide guidelines for its use in competitive sports.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 16 Years 至 50 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 16-50 years
- •well-trained cyclists
- •Proof of physical fitness (e.g. sports medical examination required) for measurements with higher intensities (e.g. endurance tests, competition simulation)
- •>10h endurance training per week
排除标准
- •Systemic disease or other known pathology in the organs: heart, lungs, kidney, stomach, spleen, liver, gall bladder, and intestines.
- •Evidence of pulmonary disease: forced expiratory volume in one second/forced expiratory volume < 70% with/without symptoms (cough, sputum) or other evidence of pulmonologic disease.
- •Diabetes II.
结局指标
主要结局
Endurance performance
时间窗: 20-30 minutes, immediately after completion of the time trial for each condition (Placebo and Verum), assessed on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).
Difference in time trial performance (average power in watts) between placebo and verum condition
次要结局
- Difference in questionnaire score - gastrointestinal symptoms(6.5 hours (rest, breakfast, every 30min during 3-hour low-intensity, after TT) for each condition (Placebo and Verum), on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in questionnaire score - Energy & Confidence(3 hours (every 30min during 3-hour low-intensity) for each condition (Placebo and Verum), assessed on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in questionnaire score - rate of perceived exertion(3.5 hours (every 30min during 3-hour low-intensity, after TT) for each condition (Placebo and Verum), assessed on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in blood count(6.5 hours (rest, every 30min during 3-hour low-intensity, after TT) for each condition (Placebo and Verum), assessed on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in pH & HCO3 kinetics(6.5 hours (rest, breakfast, every 30min during 3-hour low-intensity, after TT) for each condition (Placebo and Verum), on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in heart rate(3.5 hours, assessed continuously (every second) during 3 hour low-intensity and TT for each condition (Placebo and Verum), on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in oxygen uptake(3 hours, assessed for 5 min every 30 min during 3 hour low-intensity for each condition (Placebo and Verum), on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in blood lactate concentration(3.5 hours, assessed every 30 min during 3 hour low-intensity and after TT for each condition (Placebo and Verum), on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in substrate utilization(3 hours, assessed for 5 min every 30 min during 3 hour low-intensity for each condition (Placebo and Verum), on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in ventilation(3 hours, assessed for 5 min every 30 min during 3 hour low-intensity for each condition (Placebo and Verum), on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in core body temperature(3.5 hours, assessed continuously during 3 hour low-intensity and TT for each condition (Placebo and Verum), on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in muscle oxygenation(3.5 hours, assessed continuously during 3 hour low-intensity and TT for each condition (Placebo and Verum), on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in glucose level(24 hours, assessed continuously for each condition (Placebo and Verum), on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in sodium content(3.5 hours, assessed during 3 hour low-intensity and TT for each condition (Placebo and Verum), on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in sweat rate(3.5 hours, assessed during 3 hour low-intensity and TT for each condition (Placebo and Verum), on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
- Difference in next morning weight(24 hours, assessed in the morning for each condition (Placebo and Verum) and the following day, on test day 1 and test day 2 respectively, with a washout period of 3-7 days between appointments (test days).)
研究者
Nils Haller, PhD
Senior Researcher
University of Salzburg
研究点 (2)
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