Comparison between Fentanyl and Clonidine as an adjuvant to Ropivacaine heavy in spinal anaesthesia in lower abdominal surgeries

Not Applicable

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/12/060570
• Lead Sponsor: Office of principal midnapore medical College and hospital

Brief Summary

Comparison between intrathecal fentanyl and clonidine as adjuvants to hyperbaric ropivacaine in subarachnoid block for elective lower abdominal surgeries under spinal anaesthesia: A prospective, randomised, double blinded, comparative study.

To compare the duration of motor and sensory block of intrathecal 25mcg fentanyl and intrathecal 30mcg clonidine along with 0.75% hyperbaric ropivacaine.



To compare the post operative analgesia in patients given intrathecal fentanyl and intrathecal clonidine.



To compare the side effects and complications (if any) of the given drug during intraoperative and post operative period.



This is a hospital based, prospective, randomised, double blinded, comparative analytical study on cohort of patients posted for elective lower abdominal surgeries under subarachnoid block in general surgery operation theatre Midnapore Medical College and hospital.



As we are using equipotent dose of fentanyl and clonidine and both increases duration of block and postoperative analgesia we expect both the group receiving fentanyl and clonidine will have a longer duration of block and postoperative analgesia but among both the groups which one will provide longer duration of block and postoperative analgesia will be known after completion of the. study

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-12-18
• Study Start: 2024-01-15

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Inclusion criteria: 1.ASA grade 1&2 2.
• Age group of 18-60 years 3.
• Body mass index between 18.5-24 4.
• Elective lower abdominal surgeries under spinal anaesthesia.

Exclusion Criteria

• Patients with severe cardio- respiratory disease 2.
• Patients with hepatic and renal disease 3.
• Patients with neurological disorders 4.
• Patients with endocrine disorders 5.
• Subarachnoid block failure 6.
• Any contraindications for spinal anaesthesia 9.
• Drug allergy to study drug.

Study & Design

• Study Type: PMS
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparing block characteristics in respect to sensory block, motor block and duration of post operative analgesia	before spinal, after spinal, at 5,10,15,20,25,30,40,50,60,70, 80,90 min after spinal or till completion of surgery and 2hr, 4hr, 10hr, 14hr,18hr, 22hrs, 24 hrs post op

Secondary Outcome Measures

Name	Time	Method
1. Highest level of sensory block	2. quality of motor block

Trial Locations

Locations (1)

General surgery operation theatre; 🇮🇳 Medinipur, WEST BENGAL, India

General surgery operation theatre

🇮🇳Medinipur, WEST BENGAL, India

Ramavath Roop Singh

Principal investigator

8106697767

ramavathroopsingh150@gmail.com