Intertransverse Process Block for Quality of Recovery Post-Open Hepatectomy

Not Applicable

Not yet recruiting

• Conditions: Hepatectomy; Intertransverse Process Block; Quality of Recovery (QoR-15)

• Registration Number: NCT06957041
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

The study aims to assess the analgesic efficacy of the ITPB at the retro-SCTL space in patients undergoing major open hepatectomy surgery. This is assessed by:

Primary Objective:

Primary outcome measure:

● Assessing the quality of recovery 15 (QoR15) score at 24 and 48 hours

Secondary outcome measure:

* Number of anaesthetic and hypoesthetic dermatomes on the ventral and dorsal aspect of the thorax on both the sides at 30 minutes of block completion and during the post anaesthetic room (PACU) discharge

* Assessing the 24-hour area under the curve of postoperative pain numerical rating score (NRS, 0-10) at rest and deep breathing or upon use of triflow.

* Assessing the amount of postoperative morphine (mg) equivalent consumption at 24 and 48 hours

* Time to discharge from High dependency unit (HDU) or Intensive care unit (ICU)

Hypothesis:

The investigators hypothesize that the application of ITPB targeting the retro-SCTL space in patients undergoing open hepatectomy will improve overall quality of recovery and pain score.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-04
• Study First Submitted: 2025-04-18
• Study First Submitted QC: 2025-04-25
• Last Update Submitted: 2025-04-25
• Study Start: 2025-05-01
• Study First Posted: 2025-05-04
• Last Update Posted: 2025-05-04
• Primary Completion: 2026-07-01
• Study Completion: 2026-10-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Adult patients aged 18-75 years of ASA I - III physical status classification undergoing open hepatectomy for benign or malignant liver lesion.

Exclusion Criteria

• Patient refusal
• Patients who are unable to comprehend the QoR15 form
• Local or systemic infection
• Coagulopathy leading to absolute contraindication to regional anesthesia
• Contraindication to local anaesthetics (LA) such as LA allergy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Quality of Recovery (QOR-15)	24 and 48 hours	The QoR-15 scale is a global measure of postoperative recovery, with a score ranging from 0 (extremely poor QoR) to 150 (excellent QoR). The QoR-15 has since become the most widely reported measure of patient-assessed QoR after surgery. QoR-15 has no units.

Secondary Outcome Measures

Name	Time	Method
Time to discharge from HDU / ICU	Up to 5 days	Time to discharge from High dependency unit (HDU) or Intensive care unit (ICU) up to 5 days
Dermatomal blockade on Thorax 30 minutes upon block completion	Up to 30 minutes after block completion	To assess the number of anaesthetic and hypoesthetic dermatomes on the ventral and dorsal aspect of the thorax on both the sides at 30 minutes of block completion and during the post anaesthetic room (PACU) discharge. This will be done by ice block test. The blockade is considered positive if patient has a reduction in cold sensation over the tested dermatome compared to non-blocked areas such as forehead.
24 hours area under curve of postoperative pain score	Up to 24 hours	Assessing the 24-hour area under the curve of postoperative pain numerical rating score (NRS, 0-10) at rest and deep breathing or upon use of triflow.
Morphine consumption at 24 and 48 hours postoperatively	At 24 and 48 hours postoperatively	Assessing the amount of postoperative morphine (mg) equivalent consumption at 24 and 48 hours