DRKS00005792进行中（未招募）未知

Thrombectomy in patients ineligible for iv tPA - THRI

niversitätsKlinikum HeidelbergNeurologische KlinikAbteilung Neuroradiologie0 个研究点目标入组 4 人开始时间: 2014年5月6日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Moderate to severe stroke (NIHSS>7 and <26)
•Ineligibility for iv tPA and no prior iv tPA therapy
•Premorbid mRS 0-1
•Life expectancy > 6 Months
•Treatment can be accomplished within 8 hours after stroke onset
•Informed consent by the patient, legal guardian, or independent physician
•Imaging criteria:
•Occlusion of the M1 segment of the middle cerebral artery (MCA), and/or the intracranial segment of the distal internal carotid artery (ICA), determined by MRA or CTA
•CT and CBV map on CTP or DWI with an ASPECT score of 7-10

•Patient is eligible for and receives IV tPA according to licensing criteria
•Patient with an INR of >3
•Patient is an active participant in another drug or device treatment trial for any disease state,
•or patient is expected to start participation in another drug or device treatment trial while
•enrolled in this protocol, unless approved by Sponsor.
•Patient has pre-existing neurological or psychiatric disease that could impede the study results or would confound the neurological or functional evaluations.
•Patient has carotid dissection, high grade stenosis = 70% proximal to occlusion that requires stenting, or excessive tortuosity to gain access to occlusion, as determined by MRA/ CTA of neck and head.
•Patient has vascular disease preventing endovascular treatment (e.g. aortic dissection or aneurysm, no arterial transfemoral access)
•Patient has history of contraindication for contrast medium.
•Patient is known to have infective endocarditis
•CT scan or MRI with evidence of: Mass effect or intracranial tumor, or hypodensity on
•unenhanced CT and CBV drop on CBV maps on CTP, or, alternatively as per institutional
•standard, restricted diffusion on DWI with an ASPECT score of 6 or less
•Female of childbearing potential who is known to be pregnant and/or lactating or who has a
•positive pregnancy test on admission.
•Patients anticipated life expectancy is less than 6 Months.

发起方

niversitätsKlinikum HeidelbergNeurologische KlinikAbteilung Neuroradiologie