AI Assisted Personalized Legacy Program (Reflections: My Story) for Patients With Serious Illness

Not Applicable

Not yet recruiting

• Conditions: Serious Illness; Existential Distress

• Registration Number: NCT07009210
• Lead Sponsor: Mayo Clinic

Brief Summary

The purpose of this study is to determine if it is feasible and acceptable to recruit for and deliver the AI Assisted Personalized Legacy Program intervention to patients with serious illness.

Detailed Description

This study is an investigator-initiated, multi-site Mayo Clinic prospective minimal risk pilot study to determine feasibility and acceptability of an AI Assisted Personalized Legacy Program. The AI Assisted Personalized Legacy Program intervention is a brief, individualized psychotherapy that aims to relieve psycho-emotional and existential distress and improve the experiences of patients whose lives are impacted by serious illness. This therapy offers patients an opportunity to reflect on their life with a trained facilitator and share their thoughts and memories with family and other people in their life. The sessions are recorded and transcribed. The interventionist will work with patients to edit the document and provide a final legacy document for patient to keep and give to loved ones.

Study Timeline

• Study First Submitted: 2025-05-29
• Study First Submitted QC: 2025-05-29
• Study First Posted: 2025-06-06
• Status Verified: 2025-07
• Study Start: 2025-07-01
• Last Update Submitted: 2025-07-14
• Last Update Posted: 2025-07-15
• Primary Completion: 2026-12
• Study Completion: 2027-06-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

1. Other psychological co-morbidities such as untreated schizophrenia, bipolar disease
2. Recent suicide attempt or psychiatric illness severe enough that hospitalization has been necessary in last 6 months
3. Active delirium
4. Advanced dementia
5. Participation in concurrent legacy offerings through the palliative care clinic

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Feasibility Number	2 years	Study feasibility will be measured by the number of participants who enrolled and finished the study.
Acceptability	5-10 days post-delivery of the final legacy document	Acceptability, as measured by the 7-item Was it Worth It (WIWI Questionnaire).The questions are answered as either "yes, no, or uncertain," overall perception of quality of life change, overall perception of study experience, one open-ended feedback question, and an option to talk with someone about concerns. Positive responses indicate acceptability. Results are reported as individual items.

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States