NCT01065233已完成不适用
Genetical Predisposition in Hepatocellular Carcinoma : Pangenomic Link Study During Alcoholic Cirrhosis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,325
- 试验地点
- 4
- 主要终点
- Existence of HCC and Pangenomic analysis of DNA polymorphism
研究概览
简要总结
Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome.
The determining of a genomic mapping of " single nucleotide polymorphisms " (SNPs) permit to perform some genetic link studies with pathologies without clear hereditary disposition.
In this study, the investigators will identify predictives genetic polymorphism of HCC.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •35 to 70 years old
- •Compensated cirrhosis or not
- •Caucasian origin of the parents
- •Patient with cirrhosis (histological proof or obvious)
排除标准
- •HIV, HBV, HCV positive
- •Known Homozygotia (C282Y+/+)
- •Important hepatocytary iron overload for patient with resection
- •HCC non histologically prooved
结局指标
主要结局
Existence of HCC and Pangenomic analysis of DNA polymorphism
Existence of HCC and determination of which genetic polymorphism are predisposing to HCC or preventing for HCC
次要结局
- cirrhosis severity (compensated or not)
研究者
研究点 (4)
Loading locations...
相似试验
Unknown
不适用
Incidence of de Novo Hepatocellular Carcinoma After Antiviral Agents for HCV.Antiviral Drug Adverse ReactionHepatitis CCirrhosisNCT03775798Austral University, Argentina2,200
已完成
不适用
Risk Factors and Molecular Genomics of U.S. Patients With Chronic Liver Disease and Hepatocellular CancerCarcinoma, HepatocellularNCT01034865Stanford University750
已完成
不适用
Clinicopathological factors in hepatocellular carcinoma with microscopic portal vein invasion.Hepatocellular carcinomaJPRN-UMIN000017852Department of Gastroenterological surgery I, Hokkaido University
Unknown
不适用
Genetic Studies in Liver Cancer PatientsHepatocellular CarcinomaNCT00172640National Taiwan University Hospital40
已完成
不适用
Risk Factors of Hepatocellular Carcinomas Developed on Non-fibrotic Liver: Case-control Study (NoFlic Study)Hepatocellular CarcinomaNCT03852238University Hospital, Bordeaux283