Pangenomic Study During Alcoholic Cirrhosis

Completed

• Conditions: Alcoholic Cirrhosis

• Registration Number: NCT01065233
• Lead Sponsor: Nantes University Hospital

Brief Summary

Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome.

The determining of a genomic mapping of " single nucleotide polymorphisms " (SNPs) permit to perform some genetic link studies with pathologies without clear hereditary disposition.

In this study, the investigators will identify predictives genetic polymorphism of HCC.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-10-23
• Study First Submitted: 2010-02-08
• Study First Submitted QC: 2010-02-08
• Study First Posted: 2010-02-09
• Primary Completion: 2011-12-27
• Study Completion: 2013-07-20
• Status Verified: 2021-09
• Last Update Submitted: 2021-09-13
• Last Update Posted: 2021-09-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1325

Inclusion Criteria

• 35 to 70 years old
• Compensated cirrhosis or not
• Caucasian origin of the parents
• Patient with cirrhosis (histological proof or obvious)

Exclusion Criteria

• HIV, HBV, HCV positive
• Known Homozygotia (C282Y+/+)
• Important hepatocytary iron overload for patient with resection
• HCC non histologically prooved

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Existence of HCC and Pangenomic analysis of DNA polymorphism		Existence of HCC and determination of which genetic polymorphism are predisposing to HCC or preventing for HCC

Secondary Outcome Measures

Name	Time	Method
cirrhosis severity (compensated or not)		Analysis of the genetic polymorphism involved in the severity of cirrhosis

Trial Locations

Locations (4)

Nantes UH; 🇫🇷 Nantes, France

Jean Verdier UH; 🇫🇷 Paris, France

Paul Brousse UH; 🇫🇷 Paris, France

Rennes UH; 🇫🇷 Rennes, France