Evaluating post operative outcomes with opioid free versus opioid inclusive general anaesthesia for elective surgeries : A randomized clinical trail
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Primary outcome
研究概览
简要总结
Opioid free anaesthesia is a technique where the intraoperative use of systematic , neuraxial or intracavitary opioid is completely eliminated . restricting opioid use in anaesthesia has shown variable effectiveness in different surgeries and patient population . whereas on one hand , the opioid consumption is reduced intraoperatively, effective nociception and reduction in postoperative opioid consumption is still under investigation with OFA.
The commonly used armamentarium of non opioid analgesia includes local anaesthetics , clonidine , dexmedetomidine, ketamine , gabapentin , magnesium sulphate and dexamethasone
The spectrum of opioid free anaesthesia can be of prime utility in patient at high risk of opioid related respiratory complication such as patient with obstructive sleep apnoea , patient posted for bariatric surgeries and patient with pulmonary limitation including obstructive airway diseases
Opioid free anaesthesia also offer particular advantages in opioid tolerant patient such as patient with chronic pain , cancer related pain and patient suffering from opioid addiction .
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Aged greater than 18 years Booked for elective laparoscopic or superficial surgeries American Society of Anaesthesiologists physical status grade I-II Surgeries lasting less than 3 hrs.
排除标准
- •Pregnant women Body Mass Index greater than 35 Allergy to opioids Allergy to adjuvant drugs Persistent opioid use Non elective surgery Surgeries lasting more than 3 hrs.
结局指标
主要结局
Primary outcome
时间窗: Primary outcome | Pain parameters | Postoperative pain scores VAS scores (0-10) | 2nd hr | 8th hr | 24hr
Pain parameters
时间窗: Primary outcome | Pain parameters | Postoperative pain scores VAS scores (0-10) | 2nd hr | 8th hr | 24hr
Postoperative pain scores VAS scores (0-10)
时间窗: Primary outcome | Pain parameters | Postoperative pain scores VAS scores (0-10) | 2nd hr | 8th hr | 24hr
2nd hr
时间窗: Primary outcome | Pain parameters | Postoperative pain scores VAS scores (0-10) | 2nd hr | 8th hr | 24hr
8th hr
时间窗: Primary outcome | Pain parameters | Postoperative pain scores VAS scores (0-10) | 2nd hr | 8th hr | 24hr
24hr
时间窗: Primary outcome | Pain parameters | Postoperative pain scores VAS scores (0-10) | 2nd hr | 8th hr | 24hr
次要结局
- Secondary outcomes(PONV)