Stability of Radiomic Features for Abdominal Tumors on Contrast Enhanced CT
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 169
- 试验地点
- 4
- 主要终点
- assess the stability (reproducibility) of radiomic measurements obtained from repeat abdominal CT scans
研究概览
简要总结
The purpose of the study is to see how measurements of tumor differences vary with slight changes in CT scan parameters. Reproducible radiomic features can be extracted for abdominal tumors, and specifically colorectal liver metastases, imaged with clinical CT scanners even in the setting of variable scan parameters and variable contrast timing. Participants will be consented to undergo an additional CT of their abdomen.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients ≥ 18 years of age on the day of signed informed consent
- •Patients scheduled and approved for contrast enhanced CT that includes imaging of the abdomen and pelvis following the Department of Radiology standard of care protocol as per local institutional guidelines
- •Patients with measurable colorectal liver metastases on prior imaging, with at least one tumor greater than 2.0 cm in axial maximal diameter
排除标准
- •Patient who is pregnant and/or lactating
- •Patient scheduled for CT that includes the abdomen with a multiphasic contrast enhanced protocol (e.g. Triple Phase or Quadruple Phase Liver CT)
- •Patient who require reduced intravenous contrast dose based on the Department of Radiology contrast policy as per local institutional guidelines
- •Any other medical condition, including mental illness or substance abuse, deemed by the Investigator to be likely to interfere with a patient's ability to sign informed consent, cooperate and participate in the study, or follow up procedures
研究组 & 干预措施
Cohort 11
+ 5 second time gap between routine abdominal CT and add on CT, Noise index 14
干预措施: CT scan (Diagnostic Test)
Cohort 12
+ 5 second time gap between routine abdominal CT and add on CT, Noise index 16
干预措施: CT scan (Diagnostic Test)
Cohort 9
- 5 second time gap between routine abdominal CT and add on CT, Noise index 16
干预措施: CT scan (Diagnostic Test)
Cohort 7
- 5 second time gap between routine abdominal CT and add on CT, Noise index 12
干预措施: CT scan (Diagnostic Test)
Cohort 8
- 5 second time gap between routine abdominal CT and add on CT, Noise index 14
干预措施: CT scan (Diagnostic Test)
Cohort 6
-10 second time gap between routine abdominal CT and add on CT, Noise index 16
干预措施: CT scan (Diagnostic Test)
Cohort 10
+ 5 second time gap between routine abdominal CT and add on CT, Noise index 12
干预措施: CT scan (Diagnostic Test)
Cohort 1
-15 second time gap between routine abdominal CT and add on CT, Noise Index of 12
干预措施: CT scan (Diagnostic Test)
Cohort 2
-15 second time gap between routine abdominal CT and add on CT, Noise Index of 14
干预措施: CT scan (Diagnostic Test)
Cohort 3
-15 second time gap between routine abdominal CT and add on CT, Noise Index of 16
干预措施: CT scan (Diagnostic Test)
Cohort 4
-10 second time gap between routine abdominal CT and add on CT, Noise index 12
干预措施: CT scan (Diagnostic Test)
Cohort 5
-10 second time gap between routine abdominal CT and add on CT, Noise index 14
干预措施: CT scan (Diagnostic Test)
Cohort 13
+ 10 second time gap between routine abdominal CT and add on CT, Noise index 12
干预措施: CT scan (Diagnostic Test)
Cohort 14
+ 10 second time gap between routine abdominal CT and add on CT, Noise index 14
干预措施: CT scan (Diagnostic Test)
Cohort 15
+ 10 second time gap between routine abdominal CT and add on CT, Noise index 16
干预措施: CT scan (Diagnostic Test)
Cohort 16
+ 15 second time gap between routine abdominal CT and add on CT, Noise 12
干预措施: CT scan (Diagnostic Test)
Cohort 17
+ 15 second time gap between routine abdominal CT and add on CT, Noise 14
干预措施: CT scan (Diagnostic Test)
Cohort 18
+ 15 second time gap between routine abdominal CT and add on CT, Noise 16
干预措施: CT scan (Diagnostic Test)
结局指标
主要结局
assess the stability (reproducibility) of radiomic measurements obtained from repeat abdominal CT scans
时间窗: 2 years
There will be 18 cohorts, each cohort differing by the length of the time gap in acquisition and noise index. In addition each acquisition will be reconstructed in 21 different ways (combinations of 3 slice thicknesses and 7 ASiR levels).
次要结局
未报告次要终点