Inflammatory Stress and Periodontal Tissue Destruction in Patients With Metabolic Syndrome and Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- concentration of serum parameters
研究概览
简要总结
Metabolic syndrome and periodontitis are diseases that lower the quality of life and their incidence rates are increasing. Since both of these diseases are associated with systemic inflammation and insulin resistance, they may be comorbid. The aim of this study was to evaluate the effect of interleukin-20 (IL-20) on periodontal destruction in individuals with metabolic syndrome while considering the relationship between metabolic syndrome and periodontitis.
This study included a total of 80 individuals who were systemically and periodontally healthy (CG, n=20), were systemically healthy and had periodontitis (PG, n=20), had metabolic syndrome and were periodontally healthy (MG, n=20), or had both metabolic syndrome and periodontitis (MPG, n=20). Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all participants were required to have at least 20 teeth and be between the ages of 20 and 65 years
排除标准
- •Smokers, patients who had used antibiotics or anti-inflammatory and antioxidant drugs in the last 6 months, patients who were pregnant or lactating, those who had cancer or autoimmune diseases, and those who had undergone any periodontal treatment in the last 6 months
结局指标
主要结局
concentration of serum parameters
时间窗: 1 year
interleukin-20, RANKL, OPG, MMP-8, TOS, TAS values evaluated in serum
concentration of gingival crevicular fluid (GCF) parameters
时间窗: 1 year
interleukin-20, RANKL, OPG values evaluated in GCF.
次要结局
- value of periodontal clinical parameters(1 year)
- value of patients' clinical metabolic syndrome parameters(1 year)
研究者
Hatice Yemenoğlu
assistant professor
Recep Tayyip Erdogan University Training and Research Hospital