Cardiovascular Response to Isometric BFR Exercise

Not Applicable

Recruiting

• Conditions: Blood Pressure
• Interventions: Behavioral: Isometric handgrip exercise; Behavioral: Isometric handgrip exercise with a narrow-elastic band; Behavioral: Isometric handgrip exercise with a wide-rigid cuff

• Registration Number: NCT06529068
• Lead Sponsor: University of Texas at Austin

Brief Summary

The goal of this interventional study is to evaluate the acute impact of isometric blood flow restriction (BFR) exercise on blood pressure and other cardiovascular functions in healthy young adult volunteers. The main question it aims to answer is:

The investigators hypothesize that isometric BFR exercise with a wide-rigid cuff would lead to greater blood pressure and other cardiovascular responses and that these cardiovascular responses would be greater under isometric BFR exercise with narrow-elastic bands compared with the control condition (no cuff).

Participants will perform isometric exercises in 3 laboratory visits with different exercise conditions) no cuff control 2) BFR with wide-rigid cuff 3) BFR with narrow-elastic band.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-07-18
• Study First Submitted QC: 2024-07-25
• Study First Posted: 2024-07-31
• Status Verified: 2024-12
• Study Start: 2024-12-02
• Last Update Submitted: 2024-12-03
• Last Update Posted: 2024-12-06
• Primary Completion: 2025-07
• Study Completion: 2025-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Apparently healthy young adults aged between 18 - 40 years old and signed the informed consent.

Exclusion Criteria

• Abnormal clotting times
• Acid-base imbalance/acidosis
• Arterial calcification
• Atherosclerotic vessels
• Cardiopulmonary conditions
• Diabetes
• Dialysis/central venous access
• General/local infection
• High intracranial pressure
• Hip, pelvis, or femur fracture
• History of venous thromboembolism
• Hypertension
• Immobility for greater than 48 hours in the past month
• Immobilizing cast
• Implanted medical device
• Lymphectomies
• Obesity
• Open fracture
• Open or unhealed soft tissue injuries
• Paralysis
• Peripheral vascular disease
• Pregnancy/postpartum
• Prior revascularization
• Renal compromise
• Severe crush injuries
• Sickle cell trait/anemia
• Skin grafts
• Stroke
• Temporary nerve damage
• Thrombophilia
• Tumor/cancer
• Varicose veins
• Vascular grafting

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Isometric exercise without BFR cuff (control)	Isometric handgrip exercise	-
Isometric exercise with narrow-elastic BFR band	Isometric handgrip exercise with a narrow-elastic band	-
Isometric exercise with wide-rigid BFR cuff	Isometric handgrip exercise with a wide-rigid cuff	-

Primary Outcome Measures

Name	Time	Method
Brachial artery diameter evaluated by an ultrasound machine	Before and 20 minutes after exercise	Brachial artery diameter will be measured by an ultrasound machine to calculate flow-mediated dilation (FMD)
Heart rate	20 minutes	Monitor heart rate continuously before, during, and after exercise
Systolic blood pressure and diastolic blood pressure	20 minutes	Beat-by-beat (both systolic and diastolic blood pressure) blood pressure before, during, and after exercise

Trial Locations

Locations (1)

Cardiovascular Aging Research Laboratory; 🇺🇸 Austin, Texas, United States