Effects of Low Intensity Blood Flow Restriction on Clinical Outcomes in Women With Knee Osteoarthritis

Not Applicable

Completed

• Conditions: Osteoarthritis, Knee
• Interventions: Other: BFRT; Other: Routine Physical Therapy

• Registration Number: NCT04865692
• Lead Sponsor: University of Lahore

Brief Summary

Objective is to compare the effects of routine physical therapy with and without low intensity blood flow restriction on pain and quadriceps muscle strength in women with knee osteoarthritis.

A single blinded randomized controlled trial conducted at Department of Physiotherapy, University of Lahore Teaching Hospital, Defense Road, Lahore.

Total 60 participants were randomly assigned in to two groups, with 30 in each group The intervention group received routine physiotherapy program combined with Low Intensity Blood Flow Restriction Technique (LI-BFR. While control group were treated with only routine physiotherapy.

Dynamometer was used to assess the knee extensor strength while Knee injury and osteoarthritis outcome score was used to record any exacerbation in pain and effects of BFR on activities of daily living. Training load determined 20% of 1RM. Data analysis had done on SPSS version 23.

Detailed Description

nonparametric test Friedman test was for comparison within the groups and Mann Whitney U test was used for comparison between groups.

Randomization had done through the sealed envelope method. After allocation subjects had received their treatment protocals.

Study Timeline

• Study Start: 2018-02-15
• Primary Completion: 2020-02-15
• Study Completion: 2020-09-15
• Status Verified: 2021-04
• Study First Submitted: 2021-04-26
• Study First Submitted QC: 2021-04-26
• Last Update Submitted: 2021-04-26
• Study First Posted: 2021-04-29
• Last Update Posted: 2021-04-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• Diagnosed patients of grade II knee osteoarthritis
• Patient's age 45-65

Exclusion Criteria

• Bilateral knee replacement
• Lower limb surgery in the last six months
• Diagnosis of inflammatory joint or muscle disease
• Chest pain during exercise or at rest; or need for supplemental oxygen
• Pregnancy
• Any systemic disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Interventional group	Routine Physical Therapy	The interventional group received resisted knee extension 20% of 1RM with blood flow restriction along with routine physical therapy.
Control Group	Routine Physical Therapy	The Control group received routine physical therapy alone including knee isometrics and resisted knee extension
Interventional group	BFRT	The interventional group received resisted knee extension 20% of 1RM with blood flow restriction along with routine physical therapy.

Primary Outcome Measures

Name	Time	Method
Quadriceps muscle strength	12 Weeks	dynamometer was used to assess strength
thigh muscle size	12 weeks	measuring tape was used to measure
Pain	12 weeks	pain was measured through NPRS

Secondary Outcome Measures

Name	Time	Method
Activities of daily living	12 weeks

Trial Locations

Locations (1)

University of Lahore Teaching Hospital; 🇵🇰 Lahore, Punjab, Pakistan