Intradialytic High-Intensity Interval Training in Hemodialysis Patients

Not Applicable

Completed

• Conditions: Exercise, Compulsive; End Stage Renal Disease
• Interventions: Other: Moderate Intensity Exercise Training; Other: High Intensity Interval Exercise Training

• Registration Number: NCT05257668
• Lead Sponsor: Yasemin ASLAN KELEŞ

Brief Summary

Chronic Kidney Disease (CKD) is defined as a chronic, progressive degeneration state in the regulation of the fluid-electrolyte balance of the kidney and metabolic-endocrine functions as a result of the glomerular filtration rate (GFR) falling below 60 ml/min/1.73 m², regardless of the etiology of the kidney disease. End Stage Renal Failure (ESRD) is the last stage of CRF and is a life-threatening condition. Although the majority of ESRD patients survive on dialysis, their quality of life and functional capacity decrease due to uremic cardiomyopathy, cardiovascular diseases, anemia, diabetes mellitus, bone diseases, deconditioning, fatigue, weakness, inactivity and accompanying psychological problems.

Rehabilitation program including exercise in CKD patients; The program, which is performed under observation on non-dialysis days, can be applied in three ways: the (intradialytic) rehabilitation program performed during hemodialysis in the dialysis unit, and the home exercise program. Intradialytic exercise (IDE) is defined as exercise training performed during the hemodialysis session to increase the patient's strength and endurance and thus target various physiological and psychosocial parameters. Three types of exercises are generally recommended in the exercise program for dialysis patients. These are aerobic exercise, strengthening exercise, and combined aerobic and resistance exercise program. Aerobic exercise (both on dialysis and on non-dialysis days) is the most common type of exercise used in hemodialysis patients. It is stated that physical exercise improves the exercise capacity, muscle strength, functional capacity and quality of life of patients receiving dialysis treatment, provides blood pressure control, reduces the risk of diabetes development and cardiovascular disease, alleviates depression and anxiety symptoms, increases survival and dialysis efficiency.

When the literature is examined, no study has been found that examines how the application of high-intensity intermittent exercise training, which has very important advantages, in the intradialytic process has an effect. Therefore, the aim of our study is to compare the effects of intradialytic high-intensity intermittent exercise training and moderate-intensity exercise training on dialysis effectiveness, functional capacity and quality of life in hemodialysis patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-10-18
• Study First Submitted: 2021-11-30
• Study First Submitted QC: 2022-02-24
• Study First Posted: 2022-02-25
• Primary Completion: 2022-06-30
• Study Completion: 2022-07-30
• Status Verified: 2023-06
• Last Update Submitted: 2023-06-17
• Last Update Posted: 2023-06-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 69

Inclusion Criteria

• Between the ages of 20-65
• Having Stage 5 (ESRD) CRF according to GFR
• Literate
• Cooperative
• Dialysis treatment for at least three months

Exclusion Criteria

• History of myocardial ischemia in the last 6 months
• Uncontrollable diabetes mellitus,
• Uncontrollable hypertension
• Heart failure
• Malignant disease
• Mental retardation
• Illiteracy
• Uncooperative
• Neurological or orthopedic disability

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group 2	Moderate Intensity Exercise Training	Moderate intensity training
Group 1	High Intensity Interval Exercise Training	High intensity interval training

Primary Outcome Measures

Name	Time	Method
Dialysis Adequacy	8 weeks	Kt/V
5X Sit-to-Stand Test	8 weeks	Functional Capacity
Kidney Disease Quality of Life-36	8 weeks	Life Quality
6 Minute Walking Test	8 weeks	Functional Capacity

Secondary Outcome Measures

Name	Time	Method
Beck Depression Scale	8 weeks	Mild depression (11-17 points) Moderate depression (18-29 points) Severe depression (30-63 points)
Quadriceps muscle strength	8 weeks	Muscle testing with dynamometer
Visual Analogue Scale	8 weeks	To evaluate Fatigue. Each line is 100 mm in length - thus, scores fall between 0 and 100.Scoring : 0 : not all tired 100: extremely tired (left end of scale=not tired at all, right end of scale=extremely tired)

Trial Locations

Locations (1)

Istanbul University- Cerrahpasa; 🇹🇷 Istanbul, Turkey