The Impact of Conventional Hemodialysis and Renal Transplantation on the Global Longitudinal Strain of the Left Ventricle

Active, not recruiting

• Conditions: Chronic Kidney Diseases; Fibrosis; Cardiovascular Diseases

• Registration Number: NCT05685823
• Lead Sponsor: Grigore T. Popa University of Medicine and Pharmacy

Brief Summary

The objective of this study is to evaluate a group of patients with chronic kidney disease in stages 3-5 by conventional 2D echocardiography, tissue Doppler techniques and speckle tracking - LV GLS and determine the correlation of ultrasound parameters with mortality. Additionally, fibrosis-related biomarkers will be studied in this population.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-10-01
• Primary Completion: 2021-01-01
• Status Verified: 2023-01
• Study First Submitted: 2023-01-08
• Study First Submitted QC: 2023-01-08
• Last Update Submitted: 2023-01-08
• Study First Posted: 2023-01-17
• Last Update Posted: 2023-01-17
• Study Completion: 2023-10-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

• eGFR < 15 ml/min/1.73m2 (CKD - EPI)
• NYHA class I-II
• Hemodynamic stability

Exclusion Criteria

• age < 18 years old
• poor acoustic window
• atrial fibrillation
• recent Acute Myocardial Infarction
• pacemaker

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Variation of GLS	3 years
All-cause mortality	3 years

Trial Locations

Locations (1)

Gr T Popa University of Medicine and Pharmacy; 🇷🇴 Iasi, Romania