Evaluation of the Effect of Transvaginal Ovarian Needle Puncture on Women with Polycystic Ovary Syndrome
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 54
研究概览
简要总结
Our study included 54 Participants with clomiphene resistant PCOS women with primary or secondary infertility. The sample was divided randomly into two groups each containing 27 participants, the Control group included 27 patients received aromatase inhibitors (letrozole 2.5mg twice daily twice daily starting from 2nd day of menstrual cycle for 5 days) and FSH administered with 75 IU daily from cycle day 3 and maintained for up to 14 th of th cycle. The study group included 27 patients underwent Ultrasound-Guided Trans-vaginal Needle Ovarian puncture prior to induction of ovulation by the same previous protocol.there is no statistically significant difference between the two groups regarding LH, FSH and Testosterone levels. The LH/FSH ration in both groups is high with no statistically significant difference at 95% level of confidence.There is a marked decline in LH level in study group which was treated by trans-vaginal ovarian puncture than the control group which was reflected on LH/FSH ration which is markedly decline in the study group, Also Free testosterone showed decline in the study group. All results are statistically significant at 95% level of confidence.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 19 Year(s) 至 44 Year(s)（—）
- 性别
- Female
入选标准
- •1)Women in reproductive age (18-45 years )
- •2) All participants fulfilled the diagnosis for PCOS, two of the following three criteria:
- •A)Chronic anovulation.
- •B)Hyperandrogenism (clinical/biologic).
- •C)Polycystic ovaries on transvaginal ultrasound scan , ovarian enlargement and at least one ovary with 10–30 subcapsular follicles of 3–8 mm in diameter were present in each case.
- •3)All patients are clomiphene citrate resistant; means that women were previously treated with clomiphene citrate 100mg daily for 5 days per cycle, for 2–3 cycles, with persistent anovulation or ovulation with very thin endometrium, <5 mm at the time of HCG adminstiration.
- •4)All patients have normal TSH and prolactin level
排除标准
- •1.Previous history of ovarian drilling
- •2.previous treatment with metformin
- •3.patients with an abnormal hysterosalpingogram
- •4.previous pelvic operations
- •5.preexisting ovarian cyst on day three of the cycle
- •6.patient with husband has abnormal semen parameters