Effects of Cognitive Training on Everyday Cognitive and Brain Function in Parkinson's Disease
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Parkinson Disease
- Sponsor
- Yale University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Change in Quality of Life in Neurological Disorders Cognitive Function Version 2 (Neuro-QoL CF v2) T-scores at 6 Weeks
- Status
- Completed
- Last Updated
- 8 months ago
Overview
Brief Summary
The purpose of this research study is to determine whether cognitive training will improve cognitive and brain functions in people with Parkinson's Disease (PD) during activities of daily living using cognitive evaluations and magnetic resonance imaging (MRI).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of idiopathic PD
- •Age ≥ 40 years
- •Expected to be on a stable dopaminergic medication regimen throughout the study period
Exclusion Criteria
- •Non-English speaking
- •Pregnancy
- •Breastfeeding
- •Excessive alcohol consumption (\> 7 drinks per week for women, \> 14 drinks per week for men) or illicit substance use
- •History of a neurological disorder such as a brain tumor, stroke, central nervous system infection, multiple sclerosis, movement disorder (other than PD), or seizures
- •History of schizophrenia, bipolar disorder, attention deficit disorder, or obsessive-compulsive disorder
- •History of head injury with loss of consciousness longer than a few minutes
- •Metallic surgical implants or traumatically implanted metallic foreign bodies
- •Inability to lie flat for about an hour in the MRI scanner
- •Discomfort being in small, enclosed spaces
Outcomes
Primary Outcomes
Change in Quality of Life in Neurological Disorders Cognitive Function Version 2 (Neuro-QoL CF v2) T-scores at 6 Weeks
Time Frame: Baseline and 6 weeks
Neuro-QoL CF v2 measures self-reported levels of cognitive functioning. Raw scores are converted to standardized T-scores (mean of 50 with a standard deviation of 10). Increase in T-scores from baseline indicates improvement in everyday cognitive functioning.
Change in Neuro-QoL CF v2 T-scores at 18 Weeks
Time Frame: 18 weeks
Neuro-QoL CF v2 measures self-reported levels of cognitive functioning. Raw scores are converted to standardized T-scores (mean of 50 with a standard deviation of 10). Increase in T-scores from baseline indicates improvement in everyday cognitive functioning.
Secondary Outcomes
- Change in Composite Executive Function T-scores at 6 Weeks(6 weeks)
- Change in Composite Executive Function T-scores at 18 Weeks(18 weeks)