Interval Training Versus Electro Acupuncture on Liver Functions in Patients With Non-alcoholic Fatty Liver Disease

Not Applicable

Completed

• Conditions: Non-Alcoholic Fatty Liver Disease
• Interventions: Device: electro acupuncture; Behavioral: aerobic interval training exercise .

• Registration Number: NCT03936803
• Lead Sponsor: Cairo University

Brief Summary

in this study, the investigators compare the effect of interval training exercise and electroacupuncture on liver functions in non-alcoholic fatty liver disease patients

Detailed Description

fifty patients suffering from Nonalcoholic fatty liver disease (NAFLD) will be recruited in this study with age ranged from 30-55 years old from both sexes, chosen from internal medicine department at Kasr El Aini hospital and from the outpatient clinic of nutrition and cardiovascular disorders at the faculty of Physical Therapy Cairo University, they were divided in to two groups:Group (1):

Twenty-five patients suffering from Nonalcoholic fatty liver disease (NAFLD), and taking their standard medications In addition to electroacupuncture at points of LR3 (Taichong), LR14 (Qimen), GB 34(Yanglingquan) and ST36 (Zu San Li). Group (2):

Twenty-five patients suffering from Nonalcoholic fatty liver disease(NAFLD) and taking their standard medications in addition to aerobic interval training exercise.Lab investigations of:

Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Triglycerides (TG) and C-reactive protein (CRP).to judge liver functions

Study Timeline

• Study Start: 2017-05-01
• Primary Completion: 2018-12-05
• Study First Submitted: 2019-04-30
• Study First Submitted QC: 2019-05-02
• Study First Posted: 2019-05-03
• Study Completion: 2019-05-25
• Status Verified: 2019-11
• Last Update Submitted: 2019-11-10
• Last Update Posted: 2019-11-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Sixty patients suffering from Nonalcoholic fatty liver disease (NAFLD).
2. Their age will be ranged from 30-55 years old.
3. Body mass index (30 - 40)
4. All patients are medically stable.

Exclusion Criteria

• Patients with Hepatitis C & b
• Acute and chronic significant illnesses that may interfere with actual training, severe ventricular arrhythmia, hemodynamic deterioration or exercise-induced arrhythmia at baseline testing.
• Co-morbidities that limit exercise tolerance (hemoglobin 10 g/dl, a chronic obstructive pulmonary disease with FEV1 50%).
• Hypertension (resting blood pressure >140/90 mmHg).
• Heart failure, inability to exercise, or drug abuse.
• Pacemakers
• Pregnancy
• Epileptic Seizures
• Cancer

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
electro-acupuncture group	electro acupuncture	Twenty-five patients suffering from Nonalcoholic fatty liver disease (NAFLD), and taking their standard medications In addition to electro acupuncture (EA) of (2 Hz, 4 mA) was applied at points of: liver 3 (LR3) ,liver 14 (LR14), gall bladder 34 (GB 34) and stomach 36 (ST36) . Duration of the session was 15 min / each, three sessions per week for six weeks
exercise group	aerobic interval training exercise .	Twenty-five patients suffering from Nonalcoholic fatty liver disease (NAFLD) and taking their standard medications in addition to aerobic interval training exercise .Its consisted of cycle ergometer training, 3 days a week for 6 weeks. Aerobic interval training consisted of ( 8 )minutes warm-up, followed by 4 times of 4-minute intervals with heart rate (HR) at 85% of sub maximum HR, with active pauses of 3 minutes of walking at 60% of sub maximum heart rate HR. The exercise session was terminated by 5 minutes cool-down

Primary Outcome Measures

Name	Time	Method
lab investigations	about 14weeks	lab investigation of Triglycerides (TG) mg/dl and c-reactive protein mg/l
body mass index	about 4 weeks	was used for measuring the weight and height of each patient to calculate the body mass index (BMI) (figure). BMI = weight kg / (height m)2

Trial Locations

Locations (1)

faculty of physical therapy Cairo university; 🇪🇬 Cairo, Egypt