Interval Training and Cardio-metabolic Health in Overweight/Obese Girls

Not Applicable

Recruiting

• Conditions: Cardiometabolic Syndrome; Exercise Overtraining; Enjoyment; Obesity

• Registration Number: NCT06538714
• Lead Sponsor: Association Tunisienne d'Etude & de Recherche sur l'Athérosclérose

Brief Summary

The main purpose of this study is to compare the impact of 12-week moderate-intensity interval training (MIIT) versus combined MIIT with high-intensity interval training (HIIT) on physical fitness, cardio metabolic, lipidomic, hematological and psychological characteristics in young overweight/obese girls.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-05-20
• Study First Submitted: 2024-06-14
• Primary Completion: 2024-06-20
• Status Verified: 2024-07
• Study First Submitted QC: 2024-07-31
• Last Update Submitted: 2024-07-31
• Study First Posted: 2024-08-06
• Last Update Posted: 2024-08-06
• Study Completion: 2024-08-19

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 45

Inclusion Criteria

• Female gender,
• Overweight or obese according to the BMI classification,
• Age, 12 to 15 years,
• Personal or parental/guardian written consent

Exclusion Criteria

• Severe infectious or inflammatory diseases,
• Irregular menstrual cycles
• Participation in organized exercise training in the last 6 months or additional physical -
• recreational activities, except physical education classes.
• Using medications, hormone therapy or dietary supplements

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Changes in plasma triglycerides	12 weeks	will be assessed using an Alinity-Abbott autoanalyzer
Change in body mass index (BMI)	12 weeks	measures of weight in kilograms, height in meters, calculation of BMI in kg/m\^2)
Enjoyment	6 and 12 weeks	Enjoyment will be measured using the validated Physical Activity Enjoyment Scale. This scale was used to assess the level of enjoyment following interventions using the participants' responses to 18 items rated on a 7-point bipolar rating scale. The assessment consists of questions relateding to the enjoyment after intervention with the instruction, "Please rate how you feel about the physical activity you have been doing at the moment about the physical activity you have been doing". An overallOverall enjoyment of physical activity score was generated by summing the individual item scores. Scores ranged from 18-126, with higher scores reflecting higher levels of enjoyment.

Secondary Outcome Measures

Name	Time	Method
Changes in hematological parameters	12 weeks	Hematological parameters included red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, leukocyte count , neutrophil count , lymphocyte count, monocyte count , eosinophil count and platelet count will be measured using an automated cell counter (Sysmex XN450; Norderstedt, Germany).
Change in Heart rate	12 weeks	Heart rate will be recorded using a heart rate monitor (S810, Polar, Kempele, Finland) during the incremental running test "the Spartacus test".
Changes in Aerobic velocity	6 and 12 weeks	Aerobic velocity will be measured with incremental running test "the Spartacus test". This test is validated for the evaluation of aerobic capacity for obese adolescents. A rectangle of 750 m (75 × 10 m) will be created with different marks set at regular intervals, which represent the different speeds (from 7 to 18 km/h). Each stage lasts three minutes whereby the first stage is set at 7 km/h and each following stage increasing by 1 km/h. During each stage, the participant had 15 s to reach the corresponding mark and then 15 s of rest. Participants adjusted their running speed simultaneously to cones and audio beep. The test ended when the subject was no longer able to maintain the pace for two consecutive occasions or when he decided to stop due to exhaustion.
Changes in lipidomic profile	12 weeks	Lipidomic profile will be assessed by measuring selected plasma polyunsaturated fatty acids (PUFAs), oxylipins and endocabnnabinnoids by LC-MS/MS method
Change in sprint performance	12 weeks	Sprinting performance will be evaluated by 10-m, 20-m, 30 --m and 60-m sprints, using a series of paired photocells with an accuracy of 0.01 s (Brower Timing System, Salt Lake City, UT).

Trial Locations

Locations (2)

ATERA : Association Tunisienne d'Etude & de Recherche sur l'Athérosclérose; 🇹🇳 Tunis, Tunisia

Rabta Hospital; 🇹🇳 Tunis, Tunisia