Can brachial artery peak velocity variation and changes in this parameter in response to passive leg raising be used as a marker to predict fluid responsiveness in spontaneously breathing septic patients?

Not Applicable

Completed

• Conditions: Sepsis, spontaneously breathing patients; Infections and Infestations; Other sepsis

• Registration Number: ISRCTN37255045
• Lead Sponsor: South Tees Hospitals (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-05-08
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

1. Adults (over 18 years old)
2. Sepsis (International Sepsis Definitions Conference); confirmed presence of infectious process plus two or more:
2.1. Body temperature < 36.0 ºC or > 38.0ºC
2.2. Heart rate > 90 beats per minute
2.3. Respiratory rate > 20 breaths per minute / hyperventilation with a PaCO2 < 32mmHg
2.4. White blood cell count < 4,000/mm3 or > 12,000/mm3 or >10% immature neutrophils
3. Arterial line in place
4. Clinical need for fluid: one or more
5. Systolic blood pressure <90mmHg (or decrease of >50mmHg in previously hypertensive patients) or need for vasopressor drugs
6. Presence of oliguria (urine output < 0.5ml/kg/hr for at least two hours)
7. Tachycardia
8. Delayed capillary refill time (>2 seconds)
9. Presence of skin mottling

Exclusion Criteria

1. No consent
2. Objection from someone close who is willing to be consulted about the appropriateness of the patient who lacks mental capacity being enrolled in the study in line with the Mental Capacity Act
3. Under 18 years old
4. Pregnant
5. Mechanically ventilated
6. Evidence of fluid overload or pulmonary oedema
7. Allergy to Gelofusin
8. Unable to perform PLR (e.g. pelvic fracture)
9. Exclusion criteria after patients have already been enrolled in the study
9.1. Retrospective withdrawal of consent
9.2. Changes in vasopressor/inotropic requirements during the measurements
9.3. Changes in cardiac rhythm during the measurements

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Can brachial artery peak velocity variation (BAPVV) at baseline or changes in BAPVV in response to passive leg raising predict fluid responsiveness

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures