Grafting extraction sockets by means of deproteinized bovine bone mineral with 10% collagen (Geistlich Bio-Oss® Collagen) at the bone level and application of a collagen matrix (Geistlich Mucograft® Seal) at the soft tissue level: Histomorphometric outcome in humans after 4 months of healing
- Conditions
- K08.1Loss of teeth due to accident, extraction or local periodontal diseaseAtrophy of edentulous alveolar ridgeK08.2
- Registration Number
- DRKS00020451
- Lead Sponsor
- Danube Private University GmbH (DPU)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 11
• Adult patients of sound mind (i.e. consent patients)
• At least one primarily four-walled extraction socket
• Good general health
• Full-mouth plaque score (FMPS) = 20%
• Full-mouth bleeding score (FMBS) = 20%
• Absence of residual periodontal infection
• Scheduled for alveolar ridge preservation with DMBB+C and CM before enrolment
• Willing to adhere to a strict Supportive Periodontal Therapy (SPT) protocol
• Minors
• Pregnancy / breastfeeding
• Patients taking medications that could influence bone metabolism
• Patients with uncontrolled or poorly controlled diabetes
• Patients using anticoagulants
• Patients requiring antibiotic prophylaxis
• Smokers with more than five cig./day
• Patients with known allergic reactions/sensitivity against collagen products
• Patients presenting unstable or life-threatening conditions
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Percentage newly formed bone.<br>After a healing period of 4 to 6.5 months a biopsy with a trepan bur was taken and histomorphometric analyses done.
- Secondary Outcome Measures
Name Time Method Percentage residual bovine bone mineral and percentage new soft tissue, bone marrow.<br>After a healing period of 4 to 6.5 months a biopsy with a trepan bur was taken and histomorphometric analyses done.