Primary prevention of atopic disease by perinatal administration of probiotics
Completed
- Conditions
- Allergy, atopic disease, pregnancyPregnancy and ChildbirthAtopic disease
- Registration Number
- ISRCTN52995544
- Lead Sponsor
- niversity Medical Centre Utrecht (UMCU) (Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 120
Inclusion Criteria
Pregnant mothers were included if either they themselves or their husband plus a sibling suffered from present or past atopic disease.
Exclusion Criteria
1. Maternal use of immunomodulatory drugs during pregnancy
2. The use of probiotics
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence and severity of atopic disease at the age of 2 years.
- Secondary Outcome Measures
Name Time Method 1. SCORAD<br>2. Lung function<br>3. Serum IgE (total and specific)<br>4. Cytokines produced by peripheral blood derived mononuclear cells<br>5. Bacterial content of stools during the first weeks of life