Effect of allergen avoidance in infancy on airway inflammatio

Completed

• Conditions: Topic: Respiratory; Subtopic: Respiratory (all Subtopics); Disease: Respiratory; Respiratory; Asthma

• Registration Number: ISRCTN28233205
• Lead Sponsor: Isle of Wight Healthcare NHS Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-05-12
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Everyone (120 subjects) who participated in the original Isle of Wight Primary Prevention study will be asked if they wish to participate.

Exclusion Criteria

1. Any patient who does not wish to participate
2. Any patient where their lung function test suggests that they would be at risk of significant bronchospasm and/or clinical suspicion is high that they would not tolerate sputum induction

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
umber of sputum eosinophils in the intervention versus control group.<br><br>Sputum samples will be collected during a visit to the research centre, with preparation and analysis taking place after.

Secondary Outcome Measures

Name	Time	Method
1. Number of other cells (1) neutrophils, (2): epithelial cells in sputum in the two groups<br>2. Eosinophilic inflammatory markers (eosinophilic cationic protein and interleukin 5) in sputum supernatant in the two groups<br><br>Sputum samples will be collected during a visit to the research centre, with preparation and analysis taking place after.