Comparison between Gallium-68 citrate Positron Emission Tomography (PET-CT) and Gallium-67 citrate Single Photon Emission Computed Tomography (SPECT-CT) for infection imaging

Completed

• Conditions: Infection of bone and/or joint; Fever of unknown origin.; Infection - Studies of infection and infectious agents

• Registration Number: ACTRN12612001166864
• Lead Sponsor: Sir Charles Gairdner Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-11-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

Presents with PUO or suspected bone/joint infection
Able to undergo study procedures
Able to provide informed consent

Exclusion Criteria

Under 18 years
Pregnant or lactating at the time of SPECT-CT and PET-CT scan/s
Unable to provide informed consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess image quality and reporter confidence with Ga-68 PET-CT<br>Image quality scores, reporter confidence scores and inter-reporter agreement for Ga-68 citrate PETCT<br>will be compared with Ga-67 citrate SPECT.[At baseline];To compare Ga-68 citrate PET-CT with Ga-67 citrate SPECT-CT for diagnosing infection in patients with suspected bone/joint infection or with PUO<br>This will be assessed based on the analysis of:<br> Site(s) of Ga-67 uptake on SPECT-CT,<br> Site(s) of Ga-68 uptake on PET-CT.<br>In case of disagreement between the specialists in Nuclear Medicine and PET-CT analysing the<br>studies, the final diagnosis will be allocated based on biopsy results, results of additional imaging (CT,<br>MRI), duration of antibiotic therapy, and relevant correspondence This will be independently reviewed<br>by an Infectious diseases specialist, who will be blinded to the Ga-68 PET scan results.[At baseline]