Respiratory Effects of E-Cigarettes in Obese Youth
- Conditions
- E-Cig Use
- Interventions
- Other: ECIG ownOther: ECIG Vuse
- Registration Number
- NCT05869318
- Brief Summary
To determine vaping behaviors and respiratory function in obese and nonobese youth e-cigarette users.
- Detailed Description
The investigators hypothesize that obese youth e-cigarette users will have increased e-cigarette use that will worsen respiratory function. The approach will involve a clinical trial where vaping behaviors (using puff topography) and respiratory function (spirometry, plethysmography, and diffusion capacity) will be assessed while participants vape with their own e-cigarette and, on a separate visit, with the VUSE e-cigarette.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 56
- a current e-cigarette user (≥1 vaping bout daily) for at least the past 3 months,
- 21-25 years old,
- willing to abstain from all tobacco and nicotine for at least 12 hours prior to lab sessions,
- willing to complete five lab visits lasting up to 4 hours each,
- able to read and speak English,
- willing to provide informed consent.
- self-reported diagnosis of lung disease including asthma or cystic fibrosis
- history of cardiac event or distress within the past 3 months
- history of metabolic disease including thyroid disease or diabetes
- history of orthopedic or neuromuscular problems that preclude exercise
- currently pregnant (determined using urine pregnancy test), planning to become pregnant, delivered a child in the past 6 weeks even if not breastfeeding, or currently breastfeeding
- use of other tobacco products >10 days in the past month
- current marijuana use >10 times per month
- currently engaging in a vaping cessation attempt
- ) competitive athlete or individual currently engaged in an exercise training program involving 420min or more (moderate intensity aerobic activity) or 210 min or more (vigorous intensity aerobic activity) per week with the goal of participating in a competitive event or marathon, triathlon, etc. Participants who are engaged in usual physical activity (e.g., walking dog, biking to work, etc.) but not engaged in a "structured exercise training program" will not be excluded.
- plans to leave the Columbus or central Ohio region within the next year.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Vaping ECIG own All participants will undergo two vaping sessions: one using their own device and one using the study device Vaping ECIG Vuse All participants will undergo two vaping sessions: one using their own device and one using the study device
- Primary Outcome Measures
Name Time Method Diffusion capacity Change from 0 to 35 minutes DLCO will be completed before and after a 35 min vaping session
Forced expiratory volume in 1 second Change from 0 to 35 minutes Spirometry will be completed before and after a 35 min vaping session
Average Puff duration 35 minutes E-cig puff topography data collection for abuse liability
Functional residual capacity Change from 0 to 35 minutes Plethymosgraphy will be completed before and after a 35 min vaping session
Airway resistance Change from 0 to 35 minutes Plethymosgraphy to measure airway resistance (Raw) will be completed before and after a 35 min vaping session
Puff count 35 minutes E-cig puff topography data collection for abuse liability
Average Puff volume 35 minutes E-cig puff topography data collection for abuse liability
- Secondary Outcome Measures
Name Time Method Tiffany-Drobes Questionnaire of Smoking Urges Change from 0 to 35 minutes Assess E-cig craving/suppression of craving
Respiratory health questionnaire Change from 0 to 35 minutes Assess respiratory symptoms
Exhaled carbon monoxide Change from 0 to 35 minutes Assess carbon monoxide in exhaled air
Trial Locations
- Locations (1)
The Ohio State University
🇺🇸Columbus, Ohio, United States