ong-term lung function, exercise endurance, participation and quality of life in congenital diaphragmatic hernia

Completed

• Conditions: 10038686; congenital diaphragmatic hernia; diaphragmatic defect

• Registration Number: NL-OMON31375
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 103

Inclusion Criteria

congenital diaphragmatic hernia born between 1975 and 1986
participant in cohort studied in 1992-1994
matched controls studied in the same cohort study 1992-1994

Exclusion Criteria

refusal to participate
physical or mental disorder leading to inability to perform lung function tests and exercise endurance test adequately
serious comorbidity

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Lung function parameters<br /><br>o Lung volumes and lung clearance index<br /><br>o Airway patency<br /><br>o Diffusion capacity of the lung<br /><br>o Exhalized NO-concentration<br /><br><br /><br>Exercise endurance<br /><br>o Cardiovascular and pulmonary function dependent exercise endurance<br /><br>o Neuromuscular strength<br /><br>o Body composition </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-Fatigue<br /><br>-Pulmonary problems<br /><br>-Gastroesophageal reflux complaints<br /><br>-Participation<br /><br>-Quality of Life<br /><br>-Daily physical activity</p><br>