atural time course of lung function and respiratory muscle strength in patients with optimally treated stable heart failure with reduced ejection fractio

• Conditions: I50.1; Left ventricular failure

• Registration Number: DRKS00013902
• Lead Sponsor: Department für Neurologie - Klinik für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-03-20
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting stopped after recruiting started
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

a. Age > 18 years (no age limit)
b. able to consent
c. Diagnosis of heart failure with reduced ejection fraction -HFrEF- according to the most recent Guidelines of the European Society of Cardiology (ESC); >12 weeks since the diagnosis of HFrEF has been made; no hospitalisation for HF in the last 4 weeks; optimal medical therapy in accordance with the most recent Guidelines of the European Society of Cardiology (ESC) with no change in medication in the last 4 weeks and combination therapy for HFrEF -where there was no treatment with beta blockers or ACE Inhibitors/ARBs in HFrEF, then the reason must be documented-
d. Controls (matched for age and gender) with normal findings on echocardiogram, electrocardiogram and normal levels of natriuretic peptide hormone

Exclusion Criteria

- Body Mass Index (BMI) > 35
- Chronic obstructive pulmonary disease, emphysema
- Presence of severe neurological comorbidities especially primary myopathy, muscular dystrophy, motor neuron disease, phrenic nerve disease, epilepsy, multiple sclerosis, parkinson’s disease
- Severe psychiatric disease including dementia
- Thoracic wall disease
- Cardiac pacemaker

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Twitch transdiaphragmatic pressure after magnetic cervical stimulation of the phrenic nerves [cmH2O; measured through intraosophageal and intragastral balloon catheters with pressure recordings in response to bilateral, supramaximal cervical magnetic stimulation]