The Effects of Omega 3 and Vitamin E Supplementation on the Serum Antioxidant Enzymes and Gene Expressions of PGC-1a, h TERT, FOXOs and SIRTs in CAD Patients
Phase 4
- Conditions
- Coronary Artery Disease
- Interventions
- Dietary Supplement: omega 3Dietary Supplement: placebo of omega 3Dietary Supplement: placebo of vitamin EDietary Supplement: vitamin E
- Registration Number
- NCT02011906
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
The aim of this study is to determine the effects of omega 3 supplementation and its concurrent supplementation with vitamin E on the serum levels of antioxidant enzymes and the expressions of the PGC-1a, h TERT, FOXO1, FOXO3a , SIRT1,SIRT3, SIRT6 genes in PBMC cells in the patients with coronary artery disease
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 20
Inclusion Criteria
literate, willingness to participation, CAD patients 45- 65 years old, body mass index< 30, avoidance of dietary supplements, vitamins and herbal products at least 3 months before and throughout the intervention, willing to maintain body weight during the study
Exclusion Criteria
- people who have used vitamin E or omega 3 supplements in last 3 months, having chronic renal disease ,cancer, Hepatobilliary diseases, hematological disorders, hypo- or hyperthyroidism, diabetes, treatment with PPAR-gamma agonists or Thiazolidinediones, Smokers
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description CAD, OMEGA 3 omega 3 patients with CAD who receive 4 gr/day omega 3 in the form of 4 softgels each of them contains 1000 mg omega 3 and a softgel contains placebo of vitamin E CAD, OMEGA 3 placebo of vitamin E patients with CAD who receive 4 gr/day omega 3 in the form of 4 softgels each of them contains 1000 mg omega 3 and a softgel contains placebo of vitamin E CAD, omega 3 and vitamin E omega 3 patients with CAD who receive 4 gr/day omega 3 in the form of 4 softgels each of them contains 1000 mg omega 3 and a softgel contains 400 IU vitamin E CAD, omega 3 and vitamin E vitamin E patients with CAD who receive 4 gr/day omega 3 in the form of 4 softgels each of them contains 1000 mg omega 3 and a softgel contains 400 IU vitamin E CAD, placebo placebo of omega 3 patients with CAD who receive 4 softgels/day each of them contains placebo of omega 3 and a softgel/day contains placebo of vitamin E CAD, placebo placebo of vitamin E patients with CAD who receive 4 softgels/day each of them contains placebo of omega 3 and a softgel/day contains placebo of vitamin E
- Primary Outcome Measures
Name Time Method serum HDL cholesterol change from baseline at 2 months serum triglycerides level change from baseline at 2 months serum LDL cholesterol change from baseline at 2 months serum total cholesterol change from baseline at 2 months serum insulin change from baseline at 2 months serum Hs-CRP change from baseline at 2 months serum gluthatione peroxidase change from baseline at 2 months serum catalase change from baseline at 2 months serum superoxide dismutase change from baseline at 2 months serum total antioxidant capacity change from baseline at 2 months
- Secondary Outcome Measures
Name Time Method gene expression of SIRT1 change from baseline at 2 months gene expression of SIRT3 change from baseline at 2 months gene expression of SIRT6 change from baseline at 2 months gene expression of PGC-1a change from baseline at 2 months gene expression of FOXO3a change from baseline at 2 months gene expression of FOXO1 change from baseline at 2 months gene expression of h TERT change from baseline at 2 months
Trial Locations
- Locations (1)
Tehran University of Medical Sciences
🇮🇷Tehran, Iran, Islamic Republic of