The Effects of Omega 3 and Vitamin E Supplementation on the Serum Antioxidant Enzymes and Gene Expressions of PGC-1a, h TERT, FOXOs and SIRTs in CAD Patients
试验速览
- 阶段
- 4 期
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- serum total antioxidant capacity
研究概览
简要总结
The aim of this study is to determine the effects of omega 3 supplementation and its concurrent supplementation with vitamin E on the serum levels of antioxidant enzymes and the expressions of the PGC-1a, h TERT, FOXO1, FOXO3a , SIRT1,SIRT3, SIRT6 genes in PBMC cells in the patients with coronary artery disease
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •literate, willingness to participation, CAD patients 45- 65 years old, body mass index< 30, avoidance of dietary supplements, vitamins and herbal products at least 3 months before and throughout the intervention, willing to maintain body weight during the study
排除标准
- •people who have used vitamin E or omega 3 supplements in last 3 months, having chronic renal disease ,cancer, Hepatobilliary diseases, hematological disorders, hypo- or hyperthyroidism, diabetes, treatment with PPAR-gamma agonists or Thiazolidinediones, Smokers
结局指标
主要结局
serum total antioxidant capacity
时间窗: change from baseline at 2 months
serum total cholesterol
时间窗: change from baseline at 2 months
serum HDL cholesterol
时间窗: change from baseline at 2 months
serum triglycerides level
时间窗: change from baseline at 2 months
serum LDL cholesterol
时间窗: change from baseline at 2 months
serum insulin
时间窗: change from baseline at 2 months
serum Hs-CRP
时间窗: change from baseline at 2 months
serum gluthatione peroxidase
时间窗: change from baseline at 2 months
serum catalase
时间窗: change from baseline at 2 months
serum superoxide dismutase
时间窗: change from baseline at 2 months
次要结局
- gene expression of SIRT1(change from baseline at 2 months)
- gene expression of SIRT3(change from baseline at 2 months)
- gene expression of SIRT6(change from baseline at 2 months)
- gene expression of PGC-1a(change from baseline at 2 months)
- gene expression of FOXO3a(change from baseline at 2 months)
- gene expression of FOXO1(change from baseline at 2 months)
- gene expression of h TERT(change from baseline at 2 months)