DRKS00014074已完成未知
Down's syndrome in children males – biochemical characterisations in different media using non-randomised trial and systematic study - DSCM
Department of Basic Sciences, Faculty of Dental Medicine, Damascus University, Main Highway, AlMazaa, Damascus, Syria0 个研究点目标入组 145 人开始时间: 2018年4月10日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 145
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomized controlled study
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 2 Years 至 15 Years（—）
- 性别
- Male
入选标准
- •Males, children, Permanent residences in Damascus, Living far from plaster dust sources of any possible adjacent construction sites and far from the industrial zone (incl. concrete plants), Non-smokers (all kinds of tobacco), Non-smoker families, Unstimulated saliva samples, Controls were healthy and non-diabetic young individuals, Controls had no systemic diseases or any local infection before 3 months and did not also take any medication for at least 3 months before sample collection, DS children patients were trisomy 21 diagnosed by karyotype test and assessed by clinical examination. Patients were euthyroid at the time of study as their thyroid-stimulating hormone (TSH) and free thyroxine hormone (FT4) were within the normal range.
排除标准
- •Females, Male smokers, Smoker families, Systemic diseases, Participant takes medication for at least 3 months, Children with congenital oligodontia and delayed eruption (more than 1yr), Individuals with the history of antibiotics, anticholinergic, antihistaminic and antipsychotic therapy two weeks prior to sample collection, intervened medications that could get in the way with ions metabolisms such as taking vitamin D, aspirin, or herbal medicine which can easily interfere for instance with Fe metabolism. In addition, candidates with concentrations of thiocyanate higher than 80 mg SCN-/L (1 mg SCN-/L =17.2 µM SCN-/L) saliva or 3.00 mg SCN-/L serum were excluded from the study.
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