Assessment of Voriconazole Penetration Into the Brain by Fluorine-Magnetic Resonance Spectroscopy

Pfizer0 个研究点目标入组 12 人开始时间: 2005年4月最近更新: 2009年3月12日

适应症

试验速览

阶段: 1 期
状态: 已完成
发起方: Pfizer
入组人数: 12
主要终点: Assess brain levels of voriconazole in the brain using a non-evasive technique of MRS

研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

The purpose of this study is to determine the amount of voriconazole in the brain by fluorine-magnetic resonance spectroscopy (MRS) and to compare brain levels to plasma levels.

研究设计

研究类型: Interventional
分配方式: Non Randomized
干预模型: Single Group
盲法: None

入排标准

年龄范围: 18 Years 至 55 Years（Adult）
性别: Male
接受健康志愿者: 是

入选标准

•Healthy male volunteers 18-55 years of age

排除标准

•Subjects with any condition affecting drug absorption
•Subjects with a positive urine drug screen

结局指标

主要结局

Assess brain levels of voriconazole in the brain using a non-evasive technique of MRS

次要结局

未报告次要终点

研究者

发起方

Pfizer

申办方类型

Industry

相似试验

已完成

4 期

To Determine The Amount Of Voriconazole In The Brain After 2 Loading Doses And 3 Maintenance Doses Over 3 DaysInfections, Fungal

NCT00300677Pfizer12

已完成

4 期

Assessment of Target Site Pharmacokinetics of Voriconazole in Healthy Volunteers During Sequence TherapyHealthy

NCT01539330Martin-Luther-Universität Halle-Wittenberg9

已完成

2 期

Study Of The Pharmacokinetics And Safety Of Voriconazole In Children 2 To Less Than 15 Years Old Who Are At High Risk For Systemic Fungal InfectionAspergillosis, Aspergilloma

NCT01383993Pfizer21

已完成

不适用

Determination of Voriconazole Levels in Saliva - Validation in Specific Subsets of PatientsPneumologyHematologyInternal MedicinePediatrics

NCT01418846Universitaire Ziekenhuizen KU Leuven11

已完成

2 期

Therapeutic Drug Monitoring of VoriconazoleInvasive pulmonary aspergillosis.Invasive pulmonary aspergillosisB44.0

IRCT20151227025726N19Shahid Beheshti University of Medical Sciences24