Active celiac disease as a cardiovascular risk factor

Not Applicable

Recruiting

• Conditions: Healthy Volunteers; I70; K90.0; Coeliac disease; Atherosclerosis

• Registration Number: DRKS00029769
• Lead Sponsor: niversitätsmedizin der Johannes Gutenberg-Universität Mainz

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-08-04
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Healthy volunteers and celiac disease patients

Exclusion Criteria

Any form of disease other than celiac disease. Any long-term medication, pregnancy

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Alteration of flow-mediated dilation (FMD %) of the brachial artery will be evaluated before and after 4 weeks of gluten-free diet

Secondary Outcome Measures

Name	Time	Method
Blood pressure, heart rate, hormone levels (including incretins such as GLP-1, GLP-2 and Glucagon) inflammatory parameters as well as quality of life (Celiac Disease Questionaire CDQ). Cardiac status before and after the gluten-free diet will be examined via echocardiography. Cardiac function will be characterized via left ventricular ejection fraction, E/E’ ratio, MAPSE, tricuspid annular plane systolic excursion (TAPSE) and global longitudinal strain (GLS) as measured during echocardiography.