Pharmacokinetics of Paracetamol before and after Roux-en-Y gastric bypass

• Conditions: Morbidly obesity

• Registration Number: NL-OMON25518
• Lead Sponsor: /A

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 28

Inclusion Criteria

At least 18 years old
- On the waiting list of getting a RYGB
- Mentally competent
- Provided informed consent

Exclusion Criteria

- Undergoing different types of bariatric surgery, such as gastric band, gastric sleeve, mini gastric bypass or revision RYGB
- Previously undergone a gastric surgery, such as gastric band, RYGB or gastric sleeve
- Liver failure
- Taken PCM < 24h before blood sampling at t=0
- Allergy or intolerance for PCM
- Not being able to take PCM orally

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pharmacokinetics of paracetamol after a single oral dose of 1000 mg before and after RYGB

Secondary Outcome Measures

Name	Time	Method
Pharmacokinetics of the metabolites paracetamol glucuronide, paracetamol sulfate, paracetamol mercaptopurate and paracetamol cysteïne.<br><br>Additional secondary end points are aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase and bilirubin values before, after 6h and 24h after a single oral dose of 1000 mg PCM before and after RYGB.