Evaluation of the levels of immune response in teeth that have undergone cell death after placing simvastatin as an root canal medicine.
Phase 4
Completed
- Conditions
- Health Condition 1: K041- Necrosis of pulp
- Registration Number
- CTRI/2022/08/044749
- Lead Sponsor
- SRM Dental College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 34
Inclusion Criteria
ASA score 1
Healthy patients aged 16-60 years
patients diagnosed with pulpal necrosis and symptomatic apical periodontitis (PAI =2)
Single rooted teeth with single canal and closed apex
Exclusion Criteria
Patients under ASA 2-5 category.
Patients under any medication for a week.
Patients with periapical pathology (PAI score >2)
Teeth with cracks, vertical root fracture, internal & external resorption.
Multirooted teeth, Single rooted teeth with multiple canals.
Teeth with immature apex.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quantification and comparison of <br/ ><br>Interleukin-6 before and after <br/ ><br>placement of simvastatin will show <br/ ><br>decrease in its concentrationTimepoint: Samples will be taken before and after biomechanics preparation and after 7 days of intracanal medication placement.
- Secondary Outcome Measures
Name Time Method Quantification and comparison of <br/ ><br>Interleukin-6 before and after <br/ ><br>placement of Calcium hydroxide will <br/ ><br>show decrease in its concentration.Timepoint: Samples will be taken before and after biomechanics preparation and after 7 days of intracanal medication placement.