Role of EPA and DHA in Fish Oil on Inflammation and Lipoprotein Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Interleukin-6 (IL-6)
研究概览
简要总结
The objective of this study is to provide critical information regarding both common and distinctive roles of EPA and DHA in systemic inflammation and lipid metabolism.
详细描述
This is a randomized, placebo-controlled, double-blind, crossover study of the effects of EPA and DHA on inflammation and lipid metabolism in 24 men and women with metabolic syndrome. The study will characterize the effects of EPA alone and DHA alone, relative to each other and to placebo, on plasma biomarkers of inflammation, inflammatory cell activation and gene expression, and plasma lipid and lipoprotein levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Interleukin-6 (IL-6)
时间窗: 10 weeks
plasma levels in pg/mL
Low Density Lipoprotein Cholesterol (LDL-C)
时间窗: 10 weeks
plasma levels in mg/dL
Tumor Necrosis Factor Alpha (TNF-alpha)
时间窗: 10 weeks
plasma levels in pg/mL
次要结局
未报告次要终点
研究者
Stefania lamon-Fava
Scientist I, Associate Professor
Tufts University