Study of the Reaction of the Brain to Various Stimulations

Not Applicable

Completed

• Conditions: Corticospinal Plasticity; Neuromuscular Plasticity
• Interventions: Other: physical training; Other: mental training; Other: electrical stimulation

• Registration Number: NCT03334526
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

Physical activity is considered a therapeutic strategy in its own right in a vast majority of disabling chronic disorders. It leads to an increase in physical and probably cognitive capacity, thanks to its effects on both metabolism (muscle hypertrophy, improvement in oxidative metabolism) and the nervous system (neuroplasticity). Nonetheless, even though there is a consensus on the positive effects of physical exercise (PE) on cerebral plasticity, the physiological mechanisms by which PE affects neuroplasticity, in particular depending on the mode of muscle contraction, are still hypothetical. Moreover, several recent studies have shown that mental learning (ML) by motor imagery improves motor performance, thus making it of interest in a context of rehabilitation, in particular in situations where PE is transient of definitively impossible. Yet, the mechanisms and brain structures involved in motor learning by ML have not been established so far. Finally, on the basis of clinical observations concerning the key role of sensory input in motor function, the hypothesis that increased demand on this input by electrical stimulation (ES) as a means to improve motor function has been proposed. However, the mechanisms by which this type of stimulation could induce neuroplasticity is still to be elucidated.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-10-13
• Study First Submitted QC: 2017-11-02
• Study First Posted: 2017-11-07
• Study Start: 2017-11-09
• Primary Completion: 2022-06-24
• Study Completion: 2022-06-24
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-15
• Last Update Posted: 2023-02-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 174

Inclusion Criteria

• persons who have provided written consent
• healthy subjects
• national health insurance cover
• age 18 to 60 years

Exclusion Criteria

• personal or family history of epilepsy
• pacemakers or other apparatus likely to interfere with the magnetic field
• history of psychiatric disease
• Persons under guardianship or wards of court
• Pregnant or breast-feeding women
• problem perceived during the neurological examination which could bias the results of the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
healthy volunteers	electrical stimulation	-
healthy volunteers	physical training	-
healthy volunteers	mental training	-

Primary Outcome Measures

Name	Time	Method
level of corticospinal excitability	through study completion, an average of 4 years

Trial Locations

Locations (1)

CHU Dijon Bourgogne; 🇫🇷 Dijon, France