Effects of Physical and Cognitive Training in Neuroplasticity, Health and Cognition. Movement Project
- Conditions
- AgingCognitive Function 1, Social
- Interventions
- Behavioral: Cognitive trainingBehavioral: Combined trainingBehavioral: Physical exercise
- Registration Number
- NCT03123900
- Lead Sponsor
- University of Barcelona
- Brief Summary
The MoveMent project applies non-pharmacological strategies - physical exercise and cognitive training - that have been shown to be effective in promoting active and healthy aging. The objective is to study the molecular and neural mechanisms of these strategies to stimulate brain plasticity and improve brain health and cognitive functioning.
- Detailed Description
It is a randomized controlled study with three intervention groups - physical, cognitive and combined - and a control group. The intervention is carried out over 3 months, with a frequency of 5 weekly sessions of 45 minutes each. Cognitive training is applied through a computerized program, physical training consists of a walking aerobic program, and combined training arises from the addition of the two previous ones.
140 participants will undergo an exhaustive pre- and post-intervention evaluation that includes neuropsychological, neuroimaging, genetic and biochemical analysis before and after the intervention as well as physical and health status assessment.
The present project aims to examine the independent and combined effects of exercise and cognitive stimulation in functional and structural brain plasticity, cognitive performance, emotional state and quality of life, and will determine the demographic and clinical factors that can modulate neuroplasticity. It will allow us to study the neurophysiological mechanisms by which the different types of intervention have an effect on the structure and functioning of the brain and cognition within an omics framework.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 110
- Age between 50 and 70
- Underactive or sedentary (<2 hours a week of physical activity).
- Adequate visual, auditory and fine motor skills.
- Able to speak and understand Catalan or Spanish language.
- Accept to take part in the study and sign the informed consent according to the Declaration of Helsinki.
- Mini mental State examination < 24 and Montreal Cognitive Assessment- Short (MoCA -S) < 6.
- Diagnosis of mild cognitive impairment, dementia or other serious neurological, psychiatric, or systemic illness.
- Presence of another illness that render them unable to engage in physical activity (signs or symptoms of chronic heart disease, chronic obstructive pulmonary disease, orthopedic problems).
- History of drug abuse or alcoholism.
- Psychotropic consumption
- Contraindication to magnetic resonance imaging
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Cognitive training (n=40) Cognitive training Computerized cognitive training up to 45 minutes, 5 times a week for 3 months. Combined training (n=40) Combined training Exercise and cognitive training up to 90 minutes, 5 times a week for 3 months. Physical exercise (n= 40) Physical exercise Walking program up to 45 minutes, 5 times a week for 3 months.
- Primary Outcome Measures
Name Time Method Changes in functional and structural brain plasticity assessed with Magnetic Resonance Imaging Baseline and 3 months Resting state connectivity, structural connectivity, white matter integrity, tractography, volume of white and grey matter structures.
- Secondary Outcome Measures
Name Time Method Changes in cognitive function Baseline and 3 months Tests of executive function, attention, memory, language, visuospatial abilities and speed
Changes in emotional and functional status: Cognitive decline Baseline and 3 months Short Form of the Informant Questionnaire on Cognitive Decline in the Elderly (Short IQCODE)
Changes in emotional and functional status: Depression Baseline and 3 months Geriatric Depression Scale (GDS)
Changes in emotional and functional status: Mood Baseline and 3 months Adapted Visual Analog Mood Scale (VAMS)
Changes in emotional and functional status: Clinical outcome Baseline and 3 months Spanish version of the Clinical Outcomes in Routine Evaluation - Outcome Measure (CORE-OM)
Changes in health, fitness and physical activity: Cardiovascular risk factors Baseline and 3 months Cardiovascular risk factors
Changes in health, fitness and physical activity: Sleep Baseline and 3 months Pittsburgh Sleep quality Index
Changes in health, fitness and physical activity: Physical activity questionnaire Baseline and 3 months Spanish version of the reduced Minnesota leisure time physical and activity questionnaire (VREM)
Changes in health, fitness and physical activity: Fitness Baseline and 3 months One-mile Rockport walk test
Changes in health, fitness and physical activity: Physical activity monitoring Baseline and 3 months Polar Loop activity monitoring device.
Changes in metabolites and gene expression patterns Baseline and 3 months Metabolomic and transcriptomic analyses
Trial Locations
- Locations (1)
Centre Atenció Primària el Maresme
🇪🇸Mataro, Barcelona, Spain