Evaluation of the Relationship Between Cardiopulmonary Exercise Testing (CPET ) Abnormalities and Ca-P Status in CKD Stage3-5
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ckd-Mbd
- Sponsor
- Shahid Beheshti University of Medical Sciences
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- CPET score change
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Reductions in exercise capacity associated with exercise intolerance augment cardiovascular disease risk and predict mortality in chronic kidney disease. This study utilized cardiopulmonary exercise testing to (a) investigate mechanisms of exercise intolerance; (b) unmask subclinical ca and p and vitamin D abnormalities that may precede cardiovascular disease in chronic kidney disease.
Detailed Description
Cardiopulmonary exercise testing will carry out in Stage 3-5 chronic kidney disease patients ; estimated glomerular filtration rate \<60 ml/min/1.73 m2) and biochemistry will be added (Ca P Via D PTH FGF23).
Investigators
nooshin dalili
Principal Investigator
Shahid Beheshti University of Medical Sciences
Eligibility Criteria
Inclusion Criteria
- •CKD Patients with GFR \<60 non-dialysis
Exclusion Criteria
- •not signing consent
- •active coronary disease
Outcomes
Primary Outcomes
CPET score change
Time Frame: 12 MONTHS
Evaluation of CPET score change
Calcium x phosphorus change in stage 3-5
Time Frame: 12 MONTHS
CaxP change
Secondary Outcomes
- Renal Function change(12 MONTHS)