Relationship Between Cardiopulmonary Exercise Testing and Ca-P in Chronic Kidney Disease (CKD)

Completed

• Conditions: Ckd-Mbd

• Registration Number: NCT04013139
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Reductions in exercise capacity associated with exercise intolerance augment cardiovascular disease risk and predict mortality in chronic kidney disease. This study utilized cardiopulmonary exercise testing to (a) investigate mechanisms of exercise intolerance; (b) unmask subclinical ca and p and vitamin D abnormalities that may precede cardiovascular disease in chronic kidney disease.

Detailed Description

Cardiopulmonary exercise testing will carry out in Stage 3-5 chronic kidney disease patients ; estimated glomerular filtration rate \<60 ml/min/1.73 m2) and biochemistry will be added (Ca P Via D PTH FGF23).

Study Timeline

• Study First Submitted: 2019-06-23
• Study First Submitted QC: 2019-07-07
• Study First Posted: 2019-07-09
• Study Start: 2020-01-01
• Primary Completion: 2021-08-01
• Study Completion: 2021-10-01
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-27
• Last Update Posted: 2022-01-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• CKD Patients with GFR <60 non-dialysis
• age<18

Exclusion Criteria

• HTN
• not signing consent
• active coronary disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Calcium x phosphorus change in stage 3-5	12 MONTHS	CaxP change
CPET score change	12 MONTHS	Evaluation of CPET score change

Secondary Outcome Measures

Name	Time	Method
Renal Function change	12 MONTHS	GFR change

Trial Locations

Locations (1)

Nooshin Dalili; 🇮🇷 Tehran, Iran, Islamic Republic of