Reduced Exercise Capacity in Patients With Chronic Obstructive Pulmonary Disease -Relevance of Cardiovascular Comorbidities
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Chronic Obstructive Pulmonary Disease
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Measurement of oxygen uptake during cardiopulmonary exercise testing (% predicted)
- Last Updated
- 6 years ago
Overview
Brief Summary
In this study, cardiopulmonary exercise will be assessed to characterize the relevance of severity of COPD and coexisting cardiovascular comorbidities for exercise capacity.
Detailed Description
In patients with chronic obstructive pulmonary disease (COPD) the interpretation of dyspnoea also needs to consider coexisting cardiovascular disease. Cardiopulmonary exercise testing (CPET) is used to characterize pulmonary and cardiac function and limitations during exercise. The investigators hypothesise that cardiopulmonary exercise is reduced in COPD patients with coexisting cardiovascular disease as well as in more symptomatic patients and in patients with frequent exacerbations. For this purpose, 100 patients with with stable COPD are characterized by clinical characteristics, laboratory tests, lung function, electrocardiography, echocardiography and cardiopulmonary exercise testing.
Investigators
Klinik für Kardiologie, Pneumologie und Angiologie
Principle Investigator
Heinrich-Heine University, Duesseldorf
Eligibility Criteria
Inclusion Criteria
- •patients with stable chronic obstructive pulmonary disease, exacerbated or stable
- •40-80 years
- •sinus rhythm
- •informed written consent
Exclusion Criteria
- •Inability to give written consent
- •acute myocardial infarction with ST-segment elevations in last 30 days
- •severe acute or chronic renal dysfunction
- •severe heart failure-
- •atrial fibrillation
- •severe valve disease
- •severe hypoxemia
- •long term oxygen therapy or non invasive ventilation
Outcomes
Primary Outcomes
Measurement of oxygen uptake during cardiopulmonary exercise testing (% predicted)
Time Frame: Baseline
Secondary Outcomes
- Measurement of Maximum wattage during cardiopulmonary exercise testing(Baseline)
- Measurement of FEV1(Baseline)
- Presence of cardiovascular comorbidities(Baseline)
- N-terminal pro brain natriuretic peptid (NTproBNP) in ng/L from peripheral venous blood at baseline(Baseline)
- measurement of dyspnoea quantified by the COPD assessment test as well as the modified Medical Research Council Scale(Baseline)
- Measurement of Breathing reserve during cardiopulmonary exercise testing(Baseline)
- Measurement of Oxygen pulse during cardiopulmonary exercise testing(Baseline)
- Measurement the capillary pO2 in mmHg and capillary pCO2 at baseline(Baseline)