Physical Capacity Evaluation and Effects of ExerciseTraining on Hodgkin Lymphoma Survivors
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Hodgkin Lymphoma, Adult
- Sponsor
- University of Sao Paulo General Hospital
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Physical Capacity - Peak oxygen consumption (mL/kg/min)
- Last Updated
- 2 years ago
Overview
Brief Summary
The study aims to investigate if physical capacity obtained in the cardiopulmonary exercise test can predict cardiovascular alterations in Hodgkin Lymphoma (HL) Survivors. In addition, to study the effects of exercise training on physical capacity and cardiovascular responses in these patients.
Detailed Description
Hodgkin Lymphoma (HL) is a hematological neoplasia that mainly affects young people. Anthracycline-based chemotherapy, followed or not by mediastinal radiotherapy, substantially improves prognosis in this set of patients. Observational studies have shown that cardiovascular disease is the most non oncologic cause of death in this population. Coronary artery disease (CAD) affects 26% of survivors after 10 years of absence of HL . However, the early intervention and the assessment to predict the cardiovascular risk remain little known. In this study, the investigators will test the hypothesis that physical capacity can predict the cardiovascular alterations in HL Survivors. In addition, exercise training improves physical capacity and heart rate responses in this set of patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Hodgkin Lymphoma Survivors
- •Over 18 years old
- •Chemotherapy with anthracycline and mediastinal radiotherapy in the last 5 years or more
Exclusion Criteria
- •Renal insufficiency
- •Pregnant women,
- •Iodinated contrast allergy,
- •Life expectancy less than 1 year.
Outcomes
Primary Outcomes
Physical Capacity - Peak oxygen consumption (mL/kg/min)
Time Frame: 4 months
Oxygen consuption in crescent effort will be calculated by aggregation of volume (mL), body weight (Kg) and time (minutes).
Secondary Outcomes
- Heart Hate (beat/min)(4 months)
- Cardiac Function - Ejection Fraction(4 months)