Microbial Invasion During Parenteral Nutrition in Surgical Infants Receiving Glutamine
Phase 4
Completed
- Conditions
- Surgical Infants Requiring Total Parenteral Nutrition
- Interventions
- Drug: Dipeptiven (L-glutamine- Lalanine)Dietary Supplement: Isonitrogenous Vaminolact
- Registration Number
- NCT00647036
- Lead Sponsor
- Institute of Child Health
- Brief Summary
We hypothesise that the addition of glutamine supplementation to both parenteral nutrition and enteral feeds in surgical newborn infants leads to a reduction in bacterial invasion.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- Infants who have undergone surgical procedures for congenital anomalies or
- Intestinal inflammation who require total parenteral nutrition.
Exclusion Criteria
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 1 Dipeptiven (L-glutamine- Lalanine) Dipeptiven (L-glutamine- Lalanine) 2 Isonitrogenous Vaminolact Isonitrogenous Vaminolact
- Primary Outcome Measures
Name Time Method Evidence of microbial invasion 5 days
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie glutamine's effect on reducing bacterial translocation in neonatal parenteral nutrition?
How does glutamine supplementation compare to standard parenteral nutrition in preventing microbial invasion in surgical infants?
Which gut barrier integrity biomarkers correlate with glutamine efficacy in neonatal parenteral nutrition trials?
What adverse events are reported when adding glutamine to parenteral nutrition in neonatal surgical patients?
Are there combination therapies with glutamine that enhance microbial control in neonatal parenteral nutrition?
Trial Locations
- Locations (1)
Institute of Child Health, 30 Guilford Street
🇬🇧London, United Kingdom
Institute of Child Health, 30 Guilford Street🇬🇧London, United Kingdom