Microbial Invasion During Parenteral Nutrition in Surgical Infants Receiving Glutamine

Phase 4

Completed

• Conditions: Surgical Infants Requiring Total Parenteral Nutrition
• Interventions: Drug: Dipeptiven (L-glutamine- Lalanine); Dietary Supplement: Isonitrogenous Vaminolact

• Registration Number: NCT00647036
• Lead Sponsor: Institute of Child Health

Brief Summary

We hypothesise that the addition of glutamine supplementation to both parenteral nutrition and enteral feeds in surgical newborn infants leads to a reduction in bacterial invasion.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2008-03-26
• Study First Submitted QC: 2008-03-28
• Study First Posted: 2008-03-31
• Study Start: 2009-07
• Primary Completion: 2011-12
• Study Completion: 2012-05
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-19
• Last Update Posted: 2022-01-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Infants who have undergone surgical procedures for congenital anomalies or
• Intestinal inflammation who require total parenteral nutrition.

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
1	Dipeptiven (L-glutamine- Lalanine)	Dipeptiven (L-glutamine- Lalanine)
2	Isonitrogenous Vaminolact	Isonitrogenous Vaminolact

Primary Outcome Measures

Name	Time	Method
Evidence of microbial invasion	5 days

Trial Locations

Locations (1)

Institute of Child Health, 30 Guilford Street; 🇬🇧 London, United Kingdom