The influence of metformin and a hypocaloric diet on thyroid radioactive iodide uptake in healthy volunteers: a pilot study.
- Conditions
- fysiological Thyroid function1004373910014713
- Registration Number
- NL-OMON43413
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
* male
* No mental illness
* Informed consent
* Healthy, specifically no history of thyroid disease or renal insufficiency.
* Aged between 18-50 years
* Normal weight (BMI: 18.5-25.0 kg/m2)
* Maintained stable body weight for previous 6 months
* Mentally incompetent
* Any thyroid condition: hypo- or hyperthyroidism, thyroid cancer, other thyroid conditions.
* Any chronic illness, including diabetes mellitus, acute or chronic infections, other disease requiring treatment.
* Use of any medication or homeopathic medications. Use of paracetamol is allowed.
* Smoking
* Previous radioactive iodide scanning or other imaging techniques with administration of iodide containing contrast fluids within 6 months
* Use of supplements that contain large quantities of iodide
* Structural alcohol intake > 3 glasses/day
* Subjects who have taken part in any drug trial within 3 months prior start of this study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary endpoint is the change observed in 123I thyroid uptake measured by<br /><br>Radioactive iodide uptake testing (RAIU) before and after either metformin or<br /><br>hypocaloric dieting. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary endpoints are the changes in serum levels of TSH, fT4 and T3 before<br /><br>and after intervention. </p><br>