Remineralization Potential of Ginger and Rosemary Herbals Versus Sodium Fluoride in Treatment of White Spot Lesions

Not Applicable

• Conditions: White Spot Lesions
• Interventions: Other: ginger and rosemary gel

• Registration Number: NCT03990935
• Lead Sponsor: Cairo University

Brief Summary

To evaluate the effectiveness of ginger and rosemary herbals versus sodium fluoride in remineralization of incipient enamel caries.

Detailed Description

Group 1 (intervention)

Ginger and rosemary gel application:

First the participant will be asked to brush his/her teeth thoroughly with 1450 ppm fluoride toothpaste (Colgate total healthy clean toothpaste). Then an application of a thin ribbon of this gel to the teeth using a brush. The medication will be left for at least 1 minute. The participant will be asked to spit out the medication after use and not to swallow it. Also the participant will be asked not to rinse his/her mouth, eat, or drink for at least 30 minutes after use to get the best results.

Group 2 (control group). Sodium fluoride varnish The fluoride varnish will be bifluorid 10 single use by voco (Germany). It Contains 5 % sodium fluoride (equal to 22,600 ppm fluoride).

A thin coat will be applied on the tooth surface by using a brush. 10-20 s are sufficient for the varnish to be absorbed and then dry with air. Participants will be informed that they should not brush their teeth for 12-24 hours after the application and not to eat, or drink for at least 30 minutes after use to get the best results.

Study Timeline

• Status Verified: 2019-06
• Study First Submitted: 2019-06-13
• Study First Submitted QC: 2019-06-18
• Study First Posted: 2019-06-19
• Last Update Submitted: 2019-06-24
• Last Update Posted: 2019-06-26
• Study Start: 2019-07
• Primary Completion: 2019-12
• Study Completion: 2020-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patient who has just completed a comprehensive orthodontic treatment.
• Presence of at least one WSL, DIAGNOdent score (0-20).
• Age range between 13 and 35years.

Exclusion Criteria

• Patients with a compromised medical history.
• Severe or active periodontal disease
• Patients with developmental hypo-calcified lesions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Ginger and rosemary gel	ginger and rosemary gel	First the participant will be asked to brush his/her teeth thoroughly with 1450 ppm fluoride toothpaste (Colgate total healthy clean toothpaste). Then an application of a thin ribbon of this gel to the teeth using a brush. The medication will be left for at least 1 minute. The participant will be asked to spit out the medication after use and not to swallow it. Also the participant will be asked not to rinse his/her mouth, eat, or drink for at least 30 minutes after use to get the best results.
sodium fluoride varnish	ginger and rosemary gel	The fluoride varnish will be bifluorid 10 single use by voco (Germany). It Contains 5 % sodium fluoride (equal to 22,600 ppm fluoride). A thin coat will be applied on the tooth surface by using a brush. 10-20 s are sufficient for the varnish to be absorbed and then dry with air. Participants will be informed that they should not brush their teeth for 12-24 hours after the application and not to eat, or drink for at least 30 minutes after use to get the best results.

Primary Outcome Measures

Name	Time	Method
(white spot lesion progression)	T0 Baseline T1 1 months T2 3 months T3 6 months	The change in the lesion fluorescence will be evaluated using diode laser fluorescence device (Diagnodent).

Trial Locations

Locations (1)

Cairo University; 🇪🇬 Cairo, Egypt