Circulating and Urinary Microtranscriptome Reveal MicroRNAs Profile for Predicting Renal Recovery from Severe Acute Kidney Injury
- Conditions
- Inpatients with acute kidney injury stage III, by definition KDIGO AKI 2012 , admit at King Chulalongkorn Memorial Hospital.MicroRNAs, Renal recovery, Renal non-recovery, Acute kidney injury
- Registration Number
- TCTR20210721002
- Lead Sponsor
- The Kidney Foundation of Thailand, Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Enrolling by invitation
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
The participant must be at age 18 years or above, has Acute kidney injury stage III, according to the definition of KDIGO AKI 2012, and has urine analysis with urine RBC less than 3/HPF, and urine WBC less than 3/HPF.
Exclusion Criteria
- CKD defined as persistent glomerular filtration rate < 60 mL/min/1.73m2
for at least 3 months.
- Pregnancy
- Advanced stage of cancer
- Single kidney
- Previous history of renal replacement therapy within 30 days
- History of renal transplantation
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Discovery of miRNA expressions in urine for predicting renal recovery after acute kidney injury. 2 years NanoString nCounter system assays in dicovery phase and qRT-PCR analysis in validation phase
- Secondary Outcome Measures
Name Time Method Discovery of miRNA expressions in blood for predicting renal recovery after acute kidney injury. 2 years NanoString nCounter system assays in dicovery phase and qRT-PCR analysis in validation phase