Transcriptome analysis of circulating monocytes from patients with stable plaques and patients with unstable plaques.
- Conditions
- Cardiovascular diseaseHardening or furring of the arteries1000321610011082
- Registration Number
- NL-OMON29831
- Lead Sponsor
- Academisch Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 779
Unstable angina (IIA, IIIA, IIB, IIIB-Tneg): Clinical symptoms secondary to recent coronary plaque rupture, history of recent unstable angina, ECG repolarization abnormalities, statin treatment (> 2 months).
Stable angina patients: Stable atherosclerotic lesion(s) identified during coronary angiography, treated for more than 2 months for angina pectoris,
statin treatment (> 2 months).
Rheumatoid arthritis patients: Diagnosed as having Rheumatoid Arthritis for longer than 12 months, statin treatment (> 2 months).
Unstable angina (IIA, IIIA, IIB, IIIB-Tneg): Recent history of acute myocardial infarction (in the past year), elevated troponin-T levels, diabetic, smoker, under 18 yrs of age, clinical manifestation of extracardiac atherosclerotic disease.
Stable angina patients: Recent history of unstable angina or Acute Myocardial Infarction, diabetic, smoker, under 18 yrs of age, clinical manifestation of extracardiac atherosclerotic disease.
Rheumatoid arthritis: Clinical symptoms of atherslerotic disease, diabetic, smoker, under 18 yrs of age.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Relative gene expression levels in monocytes from different inflammatory<br /><br>disease patient groups.</p><br>
- Secondary Outcome Measures
Name Time Method <p>A questionaire concerning the habits and the disease progression of the<br /><br>patients will be conducted. This will be used in later correlation studies. A<br /><br>folow-up questionaire will be taken after 12 months</p><br>