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Immunohistochemical analysis of transcription intermediary factor-1? (TIF1-?) antibodies expression in the skin of adult anti-TIF1-? positive dermatomyositis patients

Recruiting
Conditions
M33.1
Other dermatomyositis
Registration Number
DRKS00025768
Lead Sponsor
Johannes Wesling Klinikum Universitätsklinik für Dermatologie, Venerologie, Allergologie und PhlebologieUK der Ruhr-Universität Bochum
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Recruiting
Sex
All
Target Recruitment
30
Inclusion Criteria

Diagnosed adult dermatomyositis
- Serological evidence of TIF1-gamma available
- Presence of an archived skin biopsy
- Availability of patient data (clinical and serological)
- Adult male and female patients

Exclusion Criteria

No qualitative skin sample material available

Study & Design

Study Type
observational
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Distribution of immunohistochemically measured expression (ordinal scale) of TIF1-? in skin samples from patients with TIF1-gamma positive adult dermatomyositis
Secondary Outcome Measures
NameTimeMethod
1. Association between phenotype (clinical and serological patient characteristics) and TIF1-? expression in the skin. 2. Proportion of associated malignancies in patients with TIF1-? positive adult dermatomyositis. 3. Proportion of patients with TIF1-? expression in the skin in control group (patients with TIF1-? negative adult dermatomyositis)<br>
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