Analysis of immunological and genetic signatures in pediatric inflammatory bowel diseases

• Conditions: chronic inflammation of the bowel; Inflammatory Bowel Disease; 10017969; 10021460

• Registration Number: NL-OMON48142
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

1. Patients who are suspected of having or diagnosed with VEO-IBD regardless of
race, ethnicity, and gender will be included
2. Diagnosis of IBD (Crohn disease and ulcerative colitis) is based on regular
endoscopy, histology, intestinal MRI, video capsule endoscopy or a combination
of these (IBD Working Group ESPGHAN, 2014)
3. Both parents of the identified patients will be asked to participate, in
order to perform segregation analysis, linkage analysis, or association studies
4. Written informed consent (parents and children (in case of age >12 years)

Exclusion Criteria

1. Any patient perceived by the clinical team to be at risk for complications
if collection of biospecimens samples for research purposes are taken (e.g.,
excessive bleeding)
2. No fetal specimens will be taken from pregnant women for prenatal genetic
testing
3. No Approved and signed informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To detect potential disease-causing mutations and subsequently create possible<br /><br>novel targeted treatment</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Geen</p><br>