The immunohistochemical characteristics of the obstructed human bladder
Recruiting
- Conditions
- benign prostate enlargementurinary retention10004994
- Registration Number
- NL-OMON47879
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 21
Inclusion Criteria
-Males above 18 years old with benign prostate hyperplasia
-Prostate volume of at least 60cc for which they undergo open prostatectomy
according to Hryntschak
Exclusion Criteria
-Neurological voiding disorders; including diabetes mellitus (severe or
uncontrolled, or diabetes with peripheral nerve involvement), spinal cord
injury, multiple sclerosis.
-Malignancy of the lower urinary tract, including prostate.
-Proven interstitial cystitis or clinical symptoms of interstitial cystitis.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary objective:<br /><br>To investigate whether the immunohistochemical characteristics of the bladder<br /><br>wall are different in obstructed bladders showing detrusor overactivity (DO)<br /><br>compared to obstructed bladders without detrusor overactivity and bladder<br /><br>outlet obstruction (BOO) induced urinary retention </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary objective:<br /><br>-To describe the immunohistochemical characteristics of the bladder wall and<br /><br>urethra<br /><br>-To investigate possible microanatomical connections between nerves, ganglia<br /><br>and interstitial cells in the human bladder<br /><br>-To investigate the distribution of receptors involved in bladder-urethral<br /><br>interactions in relation to bladder outlet obstruction<br /><br>-Mapping of different structures and layers of the bladder during bladder<br /><br>outlet obstruction by using two-photon laser scanning microscopy (TPLSM) </p><br>